G
Guy Drapeau
Researcher at Laval University
Publications - 94
Citations - 4977
Guy Drapeau is an academic researcher from Laval University. The author has contributed to research in topics: Receptor & Substance P. The author has an hindex of 42, co-authored 94 publications receiving 4943 citations. Previous affiliations of Guy Drapeau include Université de Sherbrooke.
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Journal ArticleDOI
New selective agonists for neurokinin receptors: pharmacological tools for receptor characterization.
TL;DR: Domenico Regoli and colleagues describe how new selective agonists developed have been successfully used in vitro to characterize the responses of peripheral organs to neurokinins, and in vivo to elucidate possible physiological roles of the neurokinin system.
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Pharmacological receptors for substance P and neurokinins.
TL;DR: A neurokinin receptor classification is attempted using the neurokinins and their fragments to determine the order of potency of agonists and some potent compounds have been identified that could provide selective receptor ligands.
Journal ArticleDOI
Selective agonists for substance P and neurokinin receptors.
TL;DR: The results of the present study indicate that a) [Sar9,Met(O2)11]SP is a potent and selective agonist for the NK-P receptors of the dog carotid artery; b) [MePhe7]NKB is a very powerful and selective stimulant of receptors for neurokinin B and c) [Nle10]NKA (4-10) is a promising compound, showing some selectivity for NK-A receptor.
Journal ArticleDOI
Receptors for substance P and related neurokinins
TL;DR: Positive significant correlations have been found for the monoreceptor (DCA, RPA, RPV) but not for the multiple receptor systems (GPI, RD, HUB), which suggests that pharmacological receptors may be identical with the recognition sites which bind the labeled neurokinins.
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New selective bradykinin receptor antagonists and bradykinin B2 receptor characterization.
TL;DR: The basic criteria of receptor characterization as they apply to kinins are reviewed and a critical analysis of the bioassay organs and B2 receptor antagonists currently used in kinin pharmacology are presented.