P
Pedro P. C. Souza
Researcher at Universidade Federal de Goiás
Publications - 41
Citations - 1542
Pedro P. C. Souza is an academic researcher from Universidade Federal de Goiás. The author has contributed to research in topics: Osteoclast & RANKL. The author has an hindex of 20, co-authored 41 publications receiving 1283 citations. Previous affiliations of Pedro P. C. Souza include Sao Paulo State University & University of São Paulo.
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Journal ArticleDOI
The role of cytokines in inflammatory bone loss
Pedro P. C. Souza,Ulf H. Lerner +1 more
TL;DR: The present overview introduces the basic concepts of osteoclast progenitor cell differentiation and summarize the current knowledge on cytokines stimulating and inhibiting osteooclastogenesis by direct and indirect mechanisms.
Journal ArticleDOI
Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma
Nádia Lago Costa,Marize Campos Valadares,Pedro P. C. Souza,Elismauro Francisco Mendonça,José Carlos de Oliveira,Tarcíla Aparecida Silva,Aline Carvalho Batista +6 more
TL;DR: A predominance of the M2 phenotype in the tumor microenvironment of OCSCC could contribute to local immunosuppression, via TGF-β production, and consequently greater lymph node involvement and reduced patient survival time.
Journal ArticleDOI
In vitro cytotoxicity and in vivo biocompatibility of contemporary resin-modified glass-ionomer cements.
Pedro P. C. Souza,Andreza Maria Fábio Aranha,Josimeri Hebling,Elisa Maria Aparecida Giro,Carlos Alberto de Souza Costa +4 more
TL;DR: Both time of elution and material significantly influenced cell respiratory activity and in general, the extracts obtained at 24 h were less cytotoxic than 48 and 72 h incubation.
Journal ArticleDOI
Porphyromonas gingivalis Stimulates Bone Resorption by Enhancing RANKL (Receptor Activator of NF-κB Ligand) through Activation of Toll-like Receptor 2 in Osteoblasts
Ali Kassem,Petra Henning,Pernilla Lundberg,Pedro P. C. Souza,Pedro P. C. Souza,Catharina Lindholm,Ulf H. Lerner,Ulf H. Lerner +7 more
TL;DR: Investigation of lipopolysaccharide from P. gingivalis shows that it stimulates periosteal osteoclast formation and bone resorption by stimulating RANKL in osteoblasts via TLR2, which might be important forperiodontal bone loss and for the enhanced bone loss seen in rheumatoid arthritis patients with concomitant periodontal disease.
Journal ArticleDOI
Participation of kallikrein-kinin system in different pathologies.
Claudio M. Costa-Neto,Patricia Dillenburg-Pilla,Tassiele A. Heinrich,Lucas T. Parreiras-e-Silva,Marilia G.A.G. Pereira,Rosana I. Reis,Pedro P. C. Souza +6 more
TL;DR: Findings concerning the participation of the kallikrein-kinin system in inflammation, cancer, and in pathologies related to cardiovascular, renal and central nervous systems are reported.