P
Pejman Ghanouni
Researcher at Stanford University
Publications - 143
Citations - 5240
Pejman Ghanouni is an academic researcher from Stanford University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 28, co-authored 109 publications receiving 4120 citations. Previous affiliations of Pejman Ghanouni include Oregon Health & Science University & Emory University.
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Journal ArticleDOI
A randomized trial of focused ultrasound thalamotomy for essential tremor
W. Jeffrey Elias,Nir Lipsman,William G. Ondo,Pejman Ghanouni,Young Gee Kim,Wonhee Lee,Michael L. Schwartz,Kullervo Hynynen,Andres M. Lozano,Binit B. Shah,Diane S. Huss,Robert F. Dallapiazza,Ryder P. Gwinn,Jennifer Witt,Susie Ro,Howard M. Eisenberg,Paul S. Fishman,Dheeraj Gandhi,Casey H. Halpern,Rosalind Chuang,Kim Butts Pauly,Travis S. Tierney,Michael T. Hayes,G. Rees Cosgrove,Toshio Yamaguchi,Keiichi Abe,Takaomi Taira,Jin Woo Chang +27 more
TL;DR: MRI-guided focused ultrasound thalamotomy reduced hand tremor in patients with essential tremor and secondary outcome measures assessing disability and quality of life improved with active treatment as compared with the sham procedure.
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Agonists induce conformational changes in transmembrane domains III and VI of the β2 adrenoceptor
Ulrik Gether,Sansan Lin,Pejman Ghanouni,Juan A. Ballesteros,Harel Weinstein,Brian K. Kobilka +5 more
TL;DR: Findings suggest that IANBD bound to 125Cys and 285Cys are exposed to a more polar environment upon agonist binding, and indicate that movements of transmembrane segments III and VI are involved in activation of G protein‐coupled receptors.
Journal ArticleDOI
Functionally Different Agonists Induce Distinct Conformations in the G Protein Coupling Domain of the β2Adrenergic Receptor
Pejman Ghanouni,Zygmunt Gryczynski,Jacqueline J. Steenhuis,Tae Weon Lee,David L. Farrens,Joseph R. Lakowicz,Brian K. Kobilka +6 more
TL;DR: Monitoring ligand-induced conformational changes in the G protein-coupling domain of the β2 adrenergic receptor provides new insight into the structural consequence of antagonist binding and the basis of agonism and partial agonism.
Journal ArticleDOI
Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor.
TL;DR: The authors' studies, when compared with studies of activation in rhodopsin, indicate a general mechanism for GPCR activation; however, a notable difference is the relatively slow kinetics of the conformational changes in the β2AR, which may reflect the different energetics of activation by diffusible ligands.
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Mutation of a Highly Conserved Aspartic Acid in the β2 Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6
Søren G. F. Rasmussen,Anne Mette Dahl Jensen,George Liapakis,Pejman Ghanouni,Jonathan A. Javitch,Ulrik Gether +5 more
TL;DR: It is proposed that protonation of the aspartic acid leads to release of constraining intramolecular interactions, resulting in movements of TM 6 and, thus, conversion of the receptor to the active state.