P
Penny E. Morton
Researcher at King's College London
Publications - 19
Citations - 672
Penny E. Morton is an academic researcher from King's College London. The author has contributed to research in topics: Cell junction & Receptor. The author has an hindex of 14, co-authored 19 publications receiving 581 citations. Previous affiliations of Penny E. Morton include Randall Division of Cell and Molecular Biophysics & Mount Vernon Hospital.
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Journal ArticleDOI
αvβ3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration
Daniel C. Worth,Kairbaan Hodivala-Dilke,Stephen D. Robinson,Samantha J King,Penny E. Morton,Frank B. Gertler,Martin J. Humphries,Maddy Parsons +7 more
TL;DR: Loss of β3 integrin enhances turnover of focal adhesions and cell migration speed due to increased β1 integrin–talin interactions.
Journal ArticleDOI
Folliculin directs the formation of a Rab34– RILP complex to control the nutrient‐dependent dynamic distribution of lysosomes
TL;DR: This model proposes a model whereby starvation‐induced FLCN association with lysosomes drives the formation of contact sites between lysoomes and Rab34‐positive peri‐nuclear membranes that restrict lysOSome motility and thus promote their retention in this region of the cell.
Journal ArticleDOI
Epithelial Inflammation Resulting from an Inherited Loss-of-Function Mutation in EGFR
Patrick Campbell,Penny E. Morton,Takuya Takeichi,Takuya Takeichi,Amr Salam,Nerys Roberts,Laura E. Proudfoot,Jemima E. Mellerio,Jemima E. Mellerio,Kingi Aminu,Cheryl Wellington,Sachin N Patil,Masashi Akiyama,Lu Liu,James R. McMillan,Sophia Aristodemou,Akemi Ishida-Yamamoto,Alya Abdul-Wahab,Gabriela Petrof,Kenneth Fong,Sarawin Harnchoowong,Kristina L. Stone,John I. Harper,W.H. Irwin McLean,Michael A. Simpson,Maddy Parsons,John A. McGrath,John A. McGrath +27 more
TL;DR: Using whole-exome sequencing, a homozygous loss-of-function missense mutation in EGFR is identified in a male infant with life-long inflammation affecting the skin, bowel and lungs and illustrates the broader impact of EGFR inhibition on other tissues.
Journal ArticleDOI
Targeted fluorescence lifetime probes reveal responsive organelle viscosity and membrane fluidity
I. E. Steinmark,Arjuna L. James,Pei-Hua Chung,Penny E. Morton,Maddy Parsons,Cécile A. Dreiss,Christian D. Lorenz,Gokhan Yahioglu,Klaus Suhling +8 more
TL;DR: A fluorescent molecular rotor/FLIM framework is presented to image both organellar viscosity and membrane fluidity, using a combination of chemical targeting and organelle extraction, and finds that both are highly dynamic and responsive to small environmental and physiological changes, even under non-pathological conditions.