T
Tony Ng
Researcher at King's College London
Publications - 181
Citations - 9335
Tony Ng is an academic researcher from King's College London. The author has contributed to research in topics: Cancer & Fluorescence-lifetime imaging microscopy. The author has an hindex of 46, co-authored 176 publications receiving 8237 citations. Previous affiliations of Tony Ng include St Thomas' Hospital & North Manchester General Hospital.
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Journal ArticleDOI
Imaging biomarker roadmap for cancer studies.
James P B O'Connor,Eric O. Aboagye,Judith E. Adams,Hugo J.W.L. Aerts,Hugo J.W.L. Aerts,Sally F. Barrington,Ambros J. Beer,Ronald Boellaard,Sarah E. Bohndiek,J. Michael Brady,Gina Brown,David L. Buckley,Thomas L. Chenevert,Laurence P. Clarke,Sandra Collette,Gary Cook,Nandita M. deSouza,John Dickson,Caroline Dive,Jeffrey L. Evelhoch,Corinne Faivre-Finn,Ferdia A. Gallagher,Fiona J. Gilbert,Robert J. Gillies,Vicky Goh,John R. Griffiths,Ashley M. Groves,Steve Halligan,Adrian L. Harris,David J. Hawkes,Otto S. Hoekstra,Erich P. Huang,Brian Hutton,Edward F. Jackson,Gordon C Jayson,Andrew J. I. Jones,Dow-Mu Koh,Denis Lacombe,Philippe Lambin,Nathalie Lassau,Martin O. Leach,Ting-Yim Lee,Edward Leen,Jason S. Lewis,Yan Liu,Mark F. Lythgoe,Prakash Manoharan,Ross J. Maxwell,Kenneth A. Miles,Bruno Morgan,Steve Morris,Tony Ng,Anwar R. Padhani,Geoff J M Parker,Mike Partridge,Arvind P. Pathak,Arvind P. Pathak,Andrew C. Peet,Shonit Punwani,Andrew R. Reynolds,Simon P. Robinson,Lalitha K. Shankar,Ricky A. Sharma,Dmitry Soloviev,Sigrid Stroobants,Daniel C. Sullivan,Stuart A. Taylor,Paul S. Tofts,Gillian M. Tozer,Marcel van Herk,Simon Walker-Samuel,James Wason,Kaye J. Williams,Paul Workman,Thomas E. Yankeelov,Kevin M. Brindle,Lisa M. McShane,Alan Jackson,John C. Waterton +78 more
TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.
Journal ArticleDOI
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
Joanna R. Morris,Chris Boutell,Melanie Keppler,Ruth M Densham,Daniel Weekes,Amin Alamshah,Laura Butler,Yaron Galanty,Laurent Pangon,Tai Kiuchi,Tony Ng,Ellen Solomon +11 more
TL;DR: It is reported that BRCA1 is modified by small ubiquitin-like modifier (SUMO) in response to genotoxic stress, and co-localizes at sites of DNA damage with SUMO1, SUMO2/3 and the SUMO-conjugating enzyme Ubc9.
Journal ArticleDOI
PKCα regulates β1 integrin‐dependent cell motility through association and control of integrin traffic
Tony Ng,David Shima,Anthony Squire,Philippe I. H. Bastiaens,Steve Gschmeissner,Martin J. Humphries,Peter J. Parker +6 more
TL;DR: Protein kinase C (PKC) has been implicated in integrin‐mediated spreading and migration in mammary epithelial cells there is a partial co‐localization between β1 integrin and PKCα and this PKC α‐enhanced migratory response is inhibited by blockade of endocytosis.
Journal ArticleDOI
Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
Tony Ng,Tony Ng,Maddy Parsons,William E. Hughes,James Monypenny,Daniel Zicha,Alexis Gautreau,Monique Arpin,Steve Gschmeissner,Peter J. Verveer,Philippe I. H. Bastiaens,Peter J. Parker +11 more
TL;DR: It is provided the first evidence that PKCα or a PKC α‐associated serine/threonine kinase can phosphorylate the ERM C‐terminal threonine residue within a kinase–ezrin molecular complex in vivo.
Journal ArticleDOI
Imaging Protein Kinase Cα Activation in Cells
Tony Ng,Anthony Squire,Gurdip Hansra,Frédéric Bornancin,Corinne Prevostel,Andrew M. Hanby,William H. Harris,Diana M. Barnes,Sandra Schmidt,Harry Mellor,Philippe I. H. Bastiaens,Peter J. Parker +11 more
TL;DR: Spatially resolved fluorescence resonance energy transfer measured by fluorescence lifetime imaging microscopy (FLIM), provides a method for tracing the catalytic activity of fluorescently tagged proteins inside live cell cultures and enables determination of the functional state of proteins in fixed cells and tissues.