P
Penny Nymark
Researcher at Karolinska Institutet
Publications - 64
Citations - 1592
Penny Nymark is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Lung cancer & Computer science. The author has an hindex of 20, co-authored 56 publications receiving 1112 citations. Previous affiliations of Penny Nymark include Helsinki University Central Hospital & Maastricht University.
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Journal ArticleDOI
Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale
Sabina Halappanavar,Sybille van den Brule,Penny Nymark,Laurent Gaté,Carole Seidel,Sarah Valentino,Vadim Zhernovkov,Pernille Høgh Danielsen,Andrea De Vizcaya,Andrea De Vizcaya,Henrik Wolff,Tobias Stöger,Andrey Boyadziev,Sarah S. Poulsen,Jorid B. Sørli,Ulla Vogel +15 more
TL;DR: A brief overview of the AOP framework and its application to nanotoxicology, tools for developing AOPs and the role of toxicogenomics are detailed, and various AOP's of relevance to inhalation toxicity of nanomaterials that are currently under various stages of development are summarized.
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Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer.
Penny Nymark,Mohamed Guled,Ioana Borze,Ali Faisal,Leo Lahti,Leo Lahti,Kaisa Salmenkivi,Eeva Kettunen,Sisko Anttila,Sisko Anttila,Sakari Knuutila +10 more
TL;DR: Novel asbestos‐related miRNAs and target genes with inverse correlation were discovered and over‐expression of the well known squamous cell carcinoma‐associated miR‐205 was linked to down‐regulation of the DOK4 gene.
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Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells
Penny Nymark,Julia Catalán,Julia Catalán,Satu Suhonen,Hilkka Järventaus,Renie K. Birkedal,Per Axel Clausen,Keld Alstrup Jensen,Minnamari Vippola,Minnamari Vippola,Kai Savolainen,Hannu Norppa +11 more
TL;DR: The lack of induction of chromosome damage by the PVP-coated AgNPs is possibly due to the coating which may protect the cells from direct interaction with the AgNPS, either by reducing ion leaching from the particles or by causing extensive agglomeration of the nanoparticles, with a possible reduction of the cellular uptake.
Journal ArticleDOI
CDK4 is a probable target gene in a novel amplicon at 12q13.3-q14.1 in lung cancer.
Harriet Wikman,Harriet Wikman,Penny Nymark,Penny Nymark,Aki Väyrynen,Sonata Jarmalaite,Anne Kallioniemi,Kaisa Salmenkivi,Katri Vainio-Siukola,Kirsti Husgafvel-Pursiainen,Sakari Knuutila,Maija Wolf,Sisko Anttila,Sisko Anttila +13 more
TL;DR: Although CDK4 amplification seems to be a relatively rare event (4.3%) in lung tumors, it indicates the significance of the RB1–CCND1 pathway in lung tumorigenesis.
Journal ArticleDOI
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines
Penny Nymark,Penny Nymark,Pamela Lindholm,Mikko Korpela,Leo Lahti,Salla Ruosaari,Salla Ruosaari,Salla Ruosaari,Samuel Kaski,Jaakko Hollmén,Sisko Anttila,Vuokko L. Kinnula,Sakari Knuutila +12 more
TL;DR: This study exposed the human cell lines A549, Beas-2B and Met5A to crocidolite asbestos and determined time-dependent gene expression profiles by using Affymetrix arrays, and identified chromosomal regions enriched with genes potentially contributing to common responses to asbestos in these cell lines.