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Per Berglund
Researcher at Royal Institute of Technology
Publications - 79
Citations - 3883
Per Berglund is an academic researcher from Royal Institute of Technology. The author has contributed to research in topics: Lipase & Active site. The author has an hindex of 30, co-authored 79 publications receiving 3510 citations. Previous affiliations of Per Berglund include Mid Sweden University & University of Toronto.
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Journal ArticleDOI
Enzyme promiscuity : mechanism and applications
Karl Hult,Per Berglund +1 more
TL;DR: Enzyme condition promiscuity has, for a long time, been used to run reactions under conditions of low water activity that favor ester synthesis instead of hydrolysis and has begun to be recognized as a valuable research and synthesis tool.
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Transaminase biocatalysis: optimization and application
Fei Guo,Per Berglund +1 more
TL;DR: This review will highlight strategies for optimization of TAs and will discuss a number of elegant systems for improving their performance.
Journal ArticleDOI
Carbon-Carbon Bonds by Hydrolytic Enzymes
TL;DR: Ser105 in CALB was targeted by site-directed mutagenesis to create enzyme variants lacking the nucleophilic feature of the active site, and it is expected that the new catalytic activity, harbored in the stable protein scaffold of the lipase, will allow aldol additions of substrates, which cannot be reached by traditional aldlases.
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Fast Carbon−Carbon Bond Formation by a Promiscuous Lipase
TL;DR: The designed Lipase B from Candida antarctica was redesigned to catalyze the promiscuous reaction of carbon-carbon bond formation and showed high rate enhancements with a catalytic proficiency higher than 108, which is on the same level as that observed for enzymes with native substrates.
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Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
Fabian Steffen-Munsberg,Clare Vickers,Hannes Kohls,Henrik Land,Hendrik Mallin,Alberto Nobili,Lilly Skalden,Tom van den Bergh,Henk-Jan Joosten,Per Berglund,Matthias Höhne,Uwe T. Bornscheuer +11 more
TL;DR: The substrate scope and the ability to accept chemically different types of substrates are shown to be reflected in conserved patterns of amino acids around the active site, which facilitates annotation and identification of biocatalytically relevant enzymes and protein engineering thereof.