Transaminase biocatalysis: optimization and application
Fei Guo,Per Berglund +1 more
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TLDR
This review will highlight strategies for optimization of TAs and will discuss a number of elegant systems for improving their performance.About:
This article is published in Green Chemistry.The article was published on 2017-01-23 and is currently open access. It has received 300 citations till now.read more
Citations
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Journal ArticleDOI
Biocatalysis: Enzymatic Synthesis for Industrial Applications
TL;DR: A review of biocatalysis with a special focus on scalable chemical production using enzymes discusses the opportunities and limitations of enzymatic syntheses using distinct examples and provides an outlook on emerging enzyme classes.
Journal ArticleDOI
Application of ω-Transaminases in the Pharmaceutical Industry
Stephen Kelly,Stefan Pohle,Scott Wharry,Stefan Mix,Christopher C. R. Allen,Thomas S. Moody,Brendan Gilmore +6 more
TL;DR: This review explores the application of ω-TAms for pharmaceutical production, providing a comprehensive overview of their uses, beginning with initial applications through to the present day.
Journal ArticleDOI
Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts
TL;DR: A detailed look into the applications of transaminases for the synthesis of a variety of amine-containing compounds and the integration of transaminaases into multienzymatic systems that allow access to a range of highly competitive compounds is presented.
Journal ArticleDOI
Biocatalysis for the synthesis of pharmaceuticals and pharmaceutical intermediates.
TL;DR: This review discusses the recent discoveries, engineering, and applications of biocatalysts for the synthesis of pharmaceuticals and pharmaceutical intermediates.
Journal ArticleDOI
A Retrosynthesis Approach for Biocatalysis in Organic Synthesis.
TL;DR: This Review highlights functional group interconversions catalyzed by enzymes, and provides some basic guidelines to choose the most appropriate enzyme for a targeted reaction keeping in mind aspects like commercial availability, cofactor-requirement, solvent tolerance, use of isolated enzymes or whole cell recombinant microorganisms aiming to assist organic chemists in the use of enzymes for synthetic applications.
References
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Journal ArticleDOI
Engineering the third wave of biocatalysis
Uwe T. Bornscheuer,Gjalt W. Huisman,Romas J. Kazlauskas,Romas J. Kazlauskas,Stefan Lutz,Jeffrey C. Moore,Karen Robins +6 more
TL;DR: Applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step are discussed.
Journal ArticleDOI
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher Savile,Jacob M. Janey,Emily Mundorff,Jeffrey C. Moore,Sarena Tam,William R. Jarvis,Jeffrey Colbeck,Anke Krebber,Fred J. Fleitz,Jos Brands,Paul N. Devine,Gjalt W. Huisman,Gregory Hughes +12 more
TL;DR: An efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin is reported, underscoring the maturation of bioc atalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.
Journal ArticleDOI
Key green chemistry research areas—a perspective from pharmaceutical manufacturers
David J. C. Constable,Peter J. Dunn,John D. Hayler,Guy R. Humphrey,Johnnie L. Leazer,Russell J. Linderman,Kurt T. Lorenz,Julie B. Manley,Bruce A. Pearlman,Andrew S. Wells,Aleksey Zaks,Tony Y. Zhang +11 more
TL;DR: An assessment of the current state of the art in green chemistry and green engineering areas and to highlight areas for future improvement are provided.
Journal ArticleDOI
Understanding enzyme immobilisation
TL;DR: This tutorial review focuses on the understanding of enzyme immobilisation, which can address the issue of enzymatic instability.
Journal ArticleDOI
Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations.
Andrew C. Eliot,Jack F. Kirsch +1 more
TL;DR: The combination of new sequences and structures enables better reconstruction of their evolutionary heritage and illuminates unrecognized similarities within this diverse group of enzymes.
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