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Per Fagerholm
Researcher at Linköping University
Publications - 194
Citations - 7396
Per Fagerholm is an academic researcher from Linköping University. The author has contributed to research in topics: Cornea & Photorefractive keratectomy. The author has an hindex of 44, co-authored 190 publications receiving 6678 citations. Previous affiliations of Per Fagerholm include Massachusetts Eye and Ear Infirmary & Karolinska Institutet.
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Journal ArticleDOI
PEG-stabilized carbodiimide crosslinked collagen-chitosan hydrogels for corneal tissue engineering.
Mehrdad Rafat,Fengfu Li,Per Fagerholm,Neil Lagali,Mitchell A. Watsky,Rejean Munger,Takeshi Matsuura,May Griffith +7 more
TL;DR: Optimum hybrid hydrogel demonstrated significantly enhanced mechanical strength and elasticity by 100 and 20%, respectively, compared to its non-hybrid counterpart and had excellent biocompatibility and when implanted into pig corneas for 12 months, allowed seamless host-graft integration with successful regeneration of host corneal epithelium, stroma, and nerves.
Journal ArticleDOI
A Biosynthetic Alternative to Human Donor Tissue for Inducing Corneal Regeneration: 24-Month Follow-Up of a Phase 1 Clinical Study
Per Fagerholm,Neil Lagali,Kimberley Merrett,W. Bruce Jackson,Rejean Munger,Yuwen Liu,James W. Polarek,Monica Söderqvist,May Griffith,May Griffith +9 more
TL;DR: A phase 1 clinical study in which biosynthetic mimics of corneal extracellular matrix were implanted to replace the pathologic anterior cornea of 10 patients who had significant vision loss, with the aim of facilitating endogenous tissue regeneration without the use of human donor tissue.
Journal ArticleDOI
Stable corneal regeneration four years after implantation of a cell-free recombinant human collagen scaffold
Per Fagerholm,Neil Lagali,Jeb A. Ong,Kimberley Merrett,W. Bruce Jackson,James W. Polarek,Erik J. Suuronen,Yuwen Liu,Isabelle Brunette,May Griffith +9 more
TL;DR: Cell-free implants, comprising carbodiimide crosslinked recombinant human collagen (RHC) can achieve stable regeneration and therefore, represent a potentially safe alternative to donor organ transplantation.
Journal ArticleDOI
Recombinant human collagen for tissue engineered corneal substitutes.
Wenguang Liu,Kimberley Merrett,May Griffith,Per Fagerholm,Subhadra Dravida,Belinda Heyne,Juan C. Scaiano,Mitchell A. Watsky,Naoshi Shinozaki,Neil Lagali,Rejean Munger,Fengfu Li +11 more
TL;DR: Transparent, robust hydrogels are fabricated as corneal substitutes from concentrated recombinant human type I and type III collagen solutions crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide and N-hydroxysuccinimide to eliminate the risk of pathogen transfer or xenogeneic immuno- responses posed by animal collagens.