P
Peter A. Bretscher
Researcher at University of Saskatchewan
Publications - 94
Citations - 5565
Peter A. Bretscher is an academic researcher from University of Saskatchewan. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 30, co-authored 87 publications receiving 5253 citations. Previous affiliations of Peter A. Bretscher include University of Alberta & ETH Zurich.
Papers
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Journal ArticleDOI
A Theory of Self- Nonself Discrimination.
Peter A. Bretscher,Melvin Cohn +1 more
TL;DR: The foregoing requirements provide an explanation for self-nonself discrimination, which involves a specific deletion in the activity of both the humoral- and the carrier-antigen-sensitive cells.
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Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major.
TL;DR: In the present study, "susceptible" mice injected with a small number of parasites mounted a cell-mediated response and acquired resistance to a larger, normally pathogenic, challenge and may be applicable in diseases in which protection is dependent on cell- mediated immunity.
Journal ArticleDOI
A two-step, two-signal model for the primary activation of precursor helper T cells
TL;DR: A new model for the primary activation of precursor helper T cells is presented, consistent with contemporary findings and incorporates a mechanism of peripheral self-nonself discrimination.
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The two-signal model of lymphocyte activation twenty-one years later
TL;DR: The extent to which the predictions of the two-signal model have been fulfilled and whether the current paradigms provide a satisfactory explanation of self-nonself discrimination are discussed.