P
Peter B. Goldsbrough
Researcher at Purdue University
Publications - 74
Citations - 9854
Peter B. Goldsbrough is an academic researcher from Purdue University. The author has contributed to research in topics: Gene & Arabidopsis. The author has an hindex of 48, co-authored 74 publications receiving 9372 citations. Previous affiliations of Peter B. Goldsbrough include University College West & University of California, Santa Cruz.
Papers
More filters
Journal ArticleDOI
PHYTOCHELATINS AND METALLOTHIONEINS: Roles in Heavy Metal Detoxification and Homeostasis
TL;DR: Recent advances in understanding the regulation of PC biosynthesis and MT gene expression and the possible roles of PCs and MTs in heavy metal detoxification and homeostasis are reviewed.
Journal ArticleDOI
Phytochelatin Synthase Genes from Arabidopsis and the Yeast Schizosaccharomyces pombe
Suk Bong Ha,Aaron P. Smith,Ross Howden,Wendy M. Dietrich,Sarah J. Bugg,Matthew J. O'Connell,Matthew J. O'Connell,Peter B. Goldsbrough,Christopher S. Cobbett +8 more
TL;DR: It is demonstrated that the S. pombe gene catalyzing GSH-dependent, heavy metal–activated synthesis of PCs in vitro demonstrated that both genes encode PC synthase activity, and a similar gene was identified in the nematode, Caenorhabditis elegans, suggesting that PCs may also be expressed in some animal species.
Journal ArticleDOI
Cadmium-Sensitive, cad1 Mutants of Arabidopsis thaliana Are Phytochelatin Deficient
TL;DR: Results demonstrate conclusively the importance of PCs for cadmium tolerance in plants and demonstrate that each mutant was deficient in PC synthase activity.
Journal ArticleDOI
A Cadmium-Sensitive, Glutathione-Deficient Mutant of Arabidopsis thaliana
TL;DR: The roots of the cadmium-sensitive mutant of Arabidopsis thaliana, cad1–1, become brown in the presence of Cadmium, and genetic analysis has shown that the sensitive phenotype is recessive to the wild type and segregates as a single Mendelian locus.
Journal ArticleDOI
Overexpression of Arabidopsis phytochelatin synthase paradoxically leads to hypersensitivity to cadmium stress.
TL;DR: Pcs lines were more sensitive to Cd than a PC-deficient Arabidopsis mutant,cad1-3, grown under low glutathione (GSH) levels, and Cd hypersensitivity in pcs lines seems due to the toxicity of PCs as they existed at supraoptimal levels when compared with GSH levels.