P
Peter K. Jeffery
Researcher at Imperial College London
Publications - 86
Citations - 9882
Peter K. Jeffery is an academic researcher from Imperial College London. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 46, co-authored 86 publications receiving 9585 citations. Previous affiliations of Peter K. Jeffery include London Chest Hospital & National Institutes of Health.
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Journal ArticleDOI
Asthma. From bronchoconstriction to airways inflammation and remodeling.
TL;DR: This work has shown that chronic inflammation in the different forms of Asthma can affect both the severity and duration of the symptoms of the disease and the treatment options for these conditions vary greatly.
Journal ArticleDOI
Remodeling in Asthma and Chronic Obstructive Lung Disease
TL;DR: In asthma several of these structural alterations begin early in the disease process, even in the child, and later in life and the associated inflammatory response differs from that in asthma.
Journal ArticleDOI
Early Thickening of the Reticular Basement Membrane in Children with Difficult Asthma
Donald Payne,Andrew V. Rogers,Ellinor Ädelroth,Venkata Bandi,Kalpalatha K. Guntupalli,Andrew Bush,Peter K. Jeffery +6 more
TL;DR: RBM thickness in the children with asthma was similar to that in adults with either mild or life-threatening asthma, and there is no association with age, symptom duration, lung function, or concurrent eosinophilic airway inflammation.
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Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial.
Eric W.F.W. Alton,M Stern,Raymond Farley,Adam Jaffe,Sharon Chadwick,J. Phillips,Jane C. Davies,Stephen N. Smith,JE Browning,Michael G. Davies,Margaret E. Hodson,Stephen R. Durham,D. Li,Peter K. Jeffery,M. Scallan,RP Balfour,Simon J. Eastman,Seng H. Cheng,Alan E. Smith,D. P. Meeker,Duncan M. Geddes +20 more
TL;DR: The safety and efficacy of cationic-lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis was studied in a double-blind placebo-controlled trial.
Journal ArticleDOI
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
Eric W.F.W. Alton,Peter G. Middleton,Natasha J. Caplen,Stephen N. Smith,D. M. Steel,Felix M. Munkonge,Peter K. Jeffery,Duncan M. Geddes,Stephen L. Hart,Robert Williamson +9 more
TL;DR: Overall, a range of correction was seen with restoration of about 50% of the deficit between wild type mice and untreated cf/cf controls, suggesting that this may offer a therapeutic alternative to adenoviral therapies.