N
Natasha J. Caplen
Researcher at National Institutes of Health
Publications - 110
Citations - 11118
Natasha J. Caplen is an academic researcher from National Institutes of Health. The author has contributed to research in topics: RNA interference & Gene silencing. The author has an hindex of 41, co-authored 103 publications receiving 10682 citations. Previous affiliations of Natasha J. Caplen include Imperial College London.
Papers
More filters
Journal ArticleDOI
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
Nozomu Yanaihara,Natasha J. Caplen,Elise D. Bowman,Masahiro Seike,Kensuke Kumamoto,Ming Yi,Robert M. Stephens,Aikou Okamoto,Jun Yokota,Tadao Tanaka,George A. Calin,Chang Gong Liu,Carlo M. Croce,Curtis C. Harris +13 more
TL;DR: Results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
Journal ArticleDOI
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems.
TL;DR: Synthetic siRNAs can induce gene-specific inhibition of expression in Caenorhabditis elegans and in cell lines from humans and mice, and seem to avoid the well documented nonspecific effects triggered by longer double-stranded RNAs in mammalian cells.
Journal ArticleDOI
Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis.
Natasha J. Caplen,Eric W.F.W. Alton,Peter G. Mddleton,Julia R. Dorin,Barbara J Stevenson,Xiang Gao,Stephen R. Durham,Peter K. Jeffery,Margaret E. Hodson,Charles Coutelle,Leaf Huang,David J. Porteous,Robert Williamson,Duncan M. Geddes +13 more
TL;DR: A partial restoration of the deficit between CF and non-CF subjects of 20% was seen for the response to low Cl− perfusion following CFTR cDNA administration and it is likely that transfection efficiency and the duration of expression will need to be increased for therapeutic benefit.
Journal ArticleDOI
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
Peter C. Scacheri,Orit Rozenblatt-Rosen,Natasha J. Caplen,Tyra G. Wolfsberg,Lowell Umayam,Jeffrey C. Lee,Christina M. Hughes,Kalai Selvi Shanmugam,Arindam Bhattacharjee,Matthew Meyerson,Francis S. Collins +10 more
TL;DR: The data suggest that siRNAs can induce nonspecific effects on protein levels that are siRNA sequence dependent but that these effects may be difficult to detect until genes central to a pivotal cellular response, such as p53 and p21, are studied.
Journal ArticleDOI
Non–invasive liposome–mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
Eric W.F.W. Alton,Peter G. Middleton,Natasha J. Caplen,Stephen N. Smith,D. M. Steel,Felix M. Munkonge,Peter K. Jeffery,Duncan M. Geddes,Stephen L. Hart,Robert Williamson +9 more
TL;DR: Overall, a range of correction was seen with restoration of about 50% of the deficit between wild type mice and untreated cf/cf controls, suggesting that this may offer a therapeutic alternative to adenoviral therapies.