P
Peter L. Carlen
Researcher at University Health Network
Publications - 385
Citations - 16408
Peter L. Carlen is an academic researcher from University Health Network. The author has contributed to research in topics: Hippocampal formation & Excitatory postsynaptic potential. The author has an hindex of 68, co-authored 377 publications receiving 15466 citations. Previous affiliations of Peter L. Carlen include Hebrew University of Jerusalem & Toronto Western Hospital.
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Source specificity of early calcium neurotoxicity in cultured embryonic spinal neurons.
TL;DR: It is found that when neurons were lethally challenged with excitatory amino acids or high K+, they experienced a biphasic increase characterized by a primary [Ca2+]i transient that decayed within minutes, followed by a secondary, sustained, and irreversible [ Ca2-i rise that indicated imminent cell death.
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Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2
Zhengping Jia,Nadia Agopyan,Peter Miu,Zhi-Gang Xiong,Jeffrey T. Henderson,Robert Gerlai,Franco A. Taverna,Alexander A. Velumian,John F. MacDonald,Peter L. Carlen,Wanda Abramow-Newerly,John C. Roder +11 more
TL;DR: In this article, GluR2 was found to play a role in the induction of long-term potentiation (LTP) in the CA1 region of hippocampal slices.
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Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans
TL;DR: Eight chronic alcoholics received repeated computed tomography scans and four, who maintained abstinence and functionally improved, showed partially reversible cerebral atrophy.
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Reduced cortical synaptic plasticity and GluR1 expression associated with fragile X mental retardation protein deficiency.
TL;DR: It is suggested that the depressed cortical GluR1 expression and LTP associated with FMRP deficiency could contribute to the Fragile X phenotype.
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Modulation of gap junctional mechanisms during calcium-free induced field burst activity: a possible role for electrotonic coupling in epileptogenesis
TL;DR: Observations indicate an apparent increase in electrotonic coupling during calcium-free induced spontaneous rhythmic field burst activity in the CA1 area of the hippocampus and that electrotonics coupling may contribute substantially to the synchronization of neuronal firing underlying seizure-like events.