Showing papers in "Molecular and Cellular Neuroscience in 2002"

TL;DR: It is suggested that the depressed cortical GluR1 expression and LTP associated with FMRP deficiency could contribute to the Fragile X phenotype.

TL;DR: The data show that estrogen, via ER, affects the proliferation and differentiation of NSC cells, probably acting in conjunction with other factors governing NSC development.

TL;DR: It is suggested that netrin-1, via DCC, influences cellular motility by regulating actin-based membrane extension through the activation of Cdc42 and Rac1.

TL;DR: A role for IL-1beta in promoting mitotic arrest and differentiation of oligodendrocyte progenitors as well as maturation and survival of differentiating oligodendedrocytes is supported.

TL;DR: The data suggest that periwound sprouting fibers grow toward the wound margin along an increasing trophic gradient generated by progressively microglial and macrophage activation.

TL;DR: The results support the idea that both mood stabilizers inhibit GSK-3beta in developing neurons through different pathways, and may have important implications for the development of new strategies to treat bipolar disorders.

TL;DR: It is suggested that syndecan-3 acts as an important modulator of synaptic plasticity that influences hippocampus-dependent memory.

TL;DR: The results indicate that Homer1 proteins regulate synaptic cycling and Ca2+ signaling of mGlu5 receptors, in response to neuronal activity.

TL;DR: Following transfection in 3T3 cells, human Robo1 and Robo2 stimulate neurite outgrowth from Robo-positive neurons (retinal neurons and olfactory neurons), but have no effect on Robo-negative neurons (cerebellar granule cells).

TL;DR: The results implicate LPA as an extracellular lipid signal affecting process outgrowth and migration of early postmitotic neurons during development.

TL;DR: Evidence is provided that cycling neuroepithelial cells pass through a neurogenic state in which they are situated apically, as defined by the capacity to express Notch1, Delta1, and Neurogenin2 (Ngn2), which suggests that INM might be important for the efficient and continued production of neurons in G0.

TL;DR: It is demonstrated for the first time that fusion of the TAT protein transduction domain to an antiapoptotic protein represents a feasible technique to rescue neurons from apoptotic degeneration in vitro and in vivo.

TL;DR: Microglia from mice lacking the IL-1beta gene demonstrated a profile of death identical to that of wild-type microglia in response to LPS and ATP, indicating that IL- 1beta is not required for P2X7 receptor-stimulated microglial death.

TL;DR: The authors' results suggest that in cortical neurons: (a) proteasomal dysfunction plays a role in formation of ubiquitin/alpha-synuclein-positive inclusions, (b) inclusion formation is an active cell process requiring transcription, and (c) ubiquitination of certain proteins is required for inclusion formation and may participate in neuronal death.

TL;DR: A cell-type-specific functional role for the three calsyntenins in excitatory synaptic transmission is suggested based on their distinct expression patterns and the differences in their cytoplasmic segments.

TL;DR: It is shown that S498 is phosphorylated by casein kinase 1 (CKI), which is consistent with a role for the cytoplasmic domain in regulating BACE trafficking and localization.

TL;DR: Observations indicate that PTEN regulates SVZ precursor cell function and is particularly important for migration and apoptosis in response to oxidative stress.

TL;DR: In both PNS and CNS neurons, the transcription of SCG10, CAP-23, and GAP-43 mRNAs is coregulated following axotomy and during regeneration, and signals from living peripheral nerve appear to maintain expression of all three m RNAs in regenerating neurons, and in PNS neurons downregulation correlates with target reinnervation.

TL;DR: The cellular localization and temporal pattern of expression of TGF β after spinal cord injury suggest that TGFβ1 modulates the inflammatory and neuronal responses, while TGFα2 regulates glial/collagen scarring.

TL;DR: It is found that sequestering BDNF in vivo with a TrkB-IgG fusion molecule significantly reduced the activation of ERK evoked by noxious stimulation, suggesting that BDNF, once released with activity from primary afferent nociceptors, exerts a neuromodulatory role in pain processing.

TL;DR: It is concluded that giant cells in human tubers likely result from a complete loss of TSC2 expression and activation of an mTOR pathway during cortical development.

TL;DR: It is shown here that nicotine can alter gene expression in rat hippocampal neurons, as reflected by activation of the transcription factor CREB and appearance of the immediate early gene product c-Fos.

TL;DR: NgR expression was not correlated with the ability of neurons to regenerate axons into nerve grafts although Nogo-66 was strongly upregulated by some cells in the distal stumps of injured sciatic nerves.

TL;DR: The present data suggest that Bral1 may play a pivotal role in the formation of the hyaluronan-associated matrix in the CNS that facilitates neuronal conduction by forming an ion diffusion barrier at the nodes.

TL;DR: This work provides the first evidence that there is a developmental switch in the use of α4 and α5 integrins during angiogenesis, and suggests that regulation of β1 integrin and ECM expression by endothelial cells are important factors influencing vascular development in the CNS.

TL;DR: A transient inhibition of I(Kir) in astrocytes in response to neuronal glutamate release and glial AMPA receptor activation represents a further, so far undetected mechanism to balance neuronal excitability.

TL;DR: It is demonstrated that the transcription factor E2F1, which is targeted by several signaling cascades that are activated by growth factors, is involved in neurogenesis in the adult brain.

TL;DR: The present findings suggest that precursor cells in neurosphere cultures, derived from distinct subregions of the embryonic telencephalon, maintain at least certain aspects of their molecular specification, even after significant expansion in vitro.

TL;DR: The results suggest that postsynaptic NMDAR activation is critical in communicating periphery-related sensory patterns from TCAs to barrel cells, and that layer IV spiny stellate cells remain imperceptive to patterning of their presynaptic inputs and elaborate exuberant dendritic specializations.

TL;DR: Replication-deficient viral vectors encoding the marker gene green fluorescent protein (GFP) were injected into the vitreous of newborn, juvenile (P14), and adult rats, and the extent of retinal cell transduction varied depending on injection age.