Peter M. May

TL;DR: The formation constants for complexes formed between Adriamycin and some transition metals are reported in this paper, where they are used to calculate the probable complex species concentrations present in gastro-intestinal fluids following Adriamcin and Quelamycin administration and to estimate the influence of the two agents upon the low-molecular-weight complexes normally present in blood plasma.

TL;DR: A reassessment of biological and chemical data reported in the literature concludes that penicillamine therapy probably produces antiinflammatory activity through more than one mechanism; it possibly has a destructive effect upon proteins that produce inflammation and also by transferring metalloprotein-bound copper into the labile pool of copper in plasma.

TL;DR: An investigation by computer simulation into the nature of Pu(IV) binding to low-molecular ligands in human blood plasma is described, and the relative ability of these and other chelating agents to cause excretion of plutonium and the concomitant loss of certain essential trace metals is assessed.

TL;DR: The role of copper in rheumatoid arthritis is discussed both from historical and experimental viewpoints as discussed by the authors, and the hypothesis that the administration of low molecular weight complexes of copper is beneficial is listed and supported with experimental evidence.