P
Peter Malone
Researcher at University College Hospital
Publications - 49
Citations - 1132
Peter Malone is an academic researcher from University College Hospital. The author has contributed to research in topics: Penile cancer & Prostate cancer. The author has an hindex of 17, co-authored 49 publications receiving 960 citations. Previous affiliations of Peter Malone include Royal Berkshire NHS Foundation Trust & Royal Berkshire Hospital.
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The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.
Jane L. Boddy,Stephen B. Fox,Cheng Han,Leticia Campo,Helen Turley,Suresh Kanga,Peter Malone,Adrian L. Harris +7 more
TL;DR: Findings confirm the relationship between hypoxia and the androgen receptor in prostate cancer, and show for the first time, the role of HIF-2a in this disease process.
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Conservative Surgery for Squamous Cell Carcinoma of the Penis: Resection Margins and Long-Term Oncological Control
Prodromos Philippou,Majid Shabbir,Peter Malone,Raj Nigam,Asif Muneer,David Ralph,Suks Minhas +6 more
TL;DR: Penile conserving surgery is oncologically safe and a surgical excision margin of less than 5 mm is adequate and higher local recurrence rates are associated with lymphovascular invasion, and higher tumor stage and grade.
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Prospective study of quantitation of plasma DNA levels in the diagnosis of malignant versus benign prostate disease
TL;DR: Elevated levels are present in the two-spin plasma samples of patients with prostate cancer compared with healthy controls but are not of diagnostic value during the management of prostate cancer.
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Epigenetics Markers of Metastasis and HPV-Induced Tumorigenesis in Penile Cancer
Andrew Feber,Manit Arya,Manit Arya,Patricia de Winter,M Saqib,Raj Nigam,Peter Malone,Wei Shen Tan,Simon Rodney,Matthias Lechner,Alex Freeman,Charles Jameson,Asif Muneer,Asif Muneer,Stephan Beck,John D. Kelly +15 more
TL;DR: These data demonstrate for the first time genome-wide epigenetic events involved in an aggressive penile cancer phenotype and define the epigenetic alterations common across multiple HPV-driven malignancies.
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CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma
Andrew Feber,Daniel C Worth,Ankur Chakravarthy,Patricia de Winter,Kunal Shah,Manit Arya,Manit Arya,M Saqib,Raj Nigam,Peter Malone,Wei Shen Tan,Simon Rodney,Alex Freeman,Charles Jameson,Gareth A. Wilson,Thomas Powles,Stephan Beck,Tim R. Fenton,Tyson V. Sharp,Asif Muneer,Asif Muneer,John D. Kelly +21 more
TL;DR: The findings of whole-exome sequencing (WES) are reported, representing the first comprehensive analysis of somatic alterations in penile cancer, highlighting the complex landscape of alterations in this malignancy.