Peter Polčic

TL;DR: It is reported that the cell death-promoting activity of BH3-only proteins Bik, Bmf, Noxa, and tBid can only be reconstituted in yeast when both multidomain proapoptotic and antiap optotic Bcl-2 family proteins are present.

TL;DR: It is shown that adenine nucleotide transport activity related to Sal1p can be demonstrated in isolated mitochondria as well as in intact cells under conditions when Aac2-mediated exchange is not functional.

TL;DR: This review focuses on using yeast expressing mammalian proteins of the Bcl-2 family as a tool to investigate mechanisms, by which these proteins permeabilize mitochondrial membranes, mechanisms,By which pro- and antiapoptotic members of this family interact, and involvement of other cellular components in the regulation of programmed cell death by Bcl -2 family proteins.

TL;DR: It is reported that cell death promoting activity of BH3‐only protein Bim can be reconstituted in yeast when both Bax and antiapoptotic protein Bcl‐XL are present, suggesting that Bim likely activates Bax indirectly by inhibiting antiapopotic proteins.

TL;DR: Aberrant mitochondrial morphology generated by either Bax or acetic acid was not accompanied with the loss of mitochondrial genome (mtDNA), indicating that alterations of mitochondrial morphology following death stimuli follow different mechanisms than those involved in mitochondrial inheritance mutants.