M
Michael Forte
Researcher at Oregon Health & Science University
Publications - 152
Citations - 12979
Michael Forte is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Mitochondrial permeability transition pore & Voltage-dependent anion channel. The author has an hindex of 57, co-authored 135 publications receiving 12215 citations. Previous affiliations of Michael Forte include University of Connecticut & University of Maryland, College Park.
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Journal ArticleDOI
Dimers of mitochondrial ATP synthase form the permeability transition pore
Valentina Giorgio,Sophia von Stockum,Manuela Antoniel,Astrid Fabbro,Federico Fogolari,Michael Forte,Gary D. Glick,Valeria Petronilli,Mario Zoratti,Ildikò Szabò,Giovanna Lippe,Paolo Bernardi +11 more
TL;DR: It is shown that CyPD binds the oligomycin sensitivity-conferring protein subunit of the enzyme at the same site as the ATP synthase inhibitor benzodiazepine 423 (Bz-423), which sensitizes the PTP to Ca2+.
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Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D
Emy Basso,Emy Basso,Lisa Fante,Jonathan Fowlkes,Valeria Petronilli,Michael Forte,Paolo Bernardi +6 more
TL;DR: The experiments demonstrate that the PTP can form and open, that CyP-D represents the target for PTP inhibition by CsA, and that Cyp-D modulates the sensitivity of the P TP to Ca2+ but not its regulation by the proton electrochemical gradient, adenine nucleotides, and oxidative stress.
Journal ArticleDOI
The mitochondrial permeability transition from in vitro artifact to disease target
Paolo Bernardi,Alexandra Krauskopf,Emy Basso,Valeria Petronilli,Elizabeth Blalchy‐Dyson,Fabio Di Lisa,Michael Forte +6 more
TL;DR: Evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease is discussed, including results based on genetic inactivation of putative permeability Transition pore components.
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Associative learning disrupted by impaired Gs signaling in Drosophila mushroom bodies
John B. Connolly,Ian J. H. Roberts,J. Douglas Armstrong,Kim Kaiser,Michael Forte,Tim Tully,Cahir J. O'Kane +6 more
TL;DR: Olfactory learning depends on regulated Gs signaling in Drosophila MBs, and the ability to associate odors with electroshock was abolished when Gαs* was targeted to MB, but not CC, structures, whereas sensorimotor responses to these stimuli remained normal.
Journal ArticleDOI
The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
Paolo Bernardi,Andrea Rasola,Andrea Rasola,Andrea Rasola,Michael Forte,Giovanna Lippe,Giovanna Lippe,Giovanna Lippe +7 more
TL;DR: Structural and functional features of F-ATP synthases are discussed that may provide clues to its transition from an energy-conserving into anEnergy-dissipating device as well as recent advances on signal transduction to the PTP and on its role in cellular pathophysiology.