Showing papers by "Peter R. Griffiths published in 1985"
TL;DR: In this article, diffuse reflectance Fourier transform infrared spectrometry was applied to reduce the widths of all bands in the spectra, and several bands absorbing between 3000 and 2800 cm−1 due to C-H stretching modes of alkyl groups in different environments couId be resolved.
255 citations
TL;DR: Fourier selfdeconvolution (FSD) has been employed to enhance the resolution of the infrared spectra of proteins in the solid state and in D2O solution as mentioned in this paper.
Abstract: Fourier self-deconvolution (FSD) has been employed to enhance the resolution of the infrared spectra of proteins in the solid state and in D2O solution. The feasibility of using diffuse reflectance spectrometry for measuring the infrared spectra of solid proteins has been demonstrated. FSD permits inherently broad absorption bands to be resolved into distinct peaks which can be associated with specific protein secondary structures. Because the areas of the resolved peaks are the same as the areas of the previously unidentifiable components, this new method should enable quantitative estimates of the proportion of each conformation in a protein to be calculated.
168 citations
TL;DR: The effects of oral sulindac on renal hemodynamics were studied in normal subjects, elderly persons with mild renal failure, and patients with chronic renal disease, finding none of these changes are likely to be of major clinical significance.
Abstract: The effects of oral sulindac on renal hemodynamics were studied in normal subjects, elderly persons with mild renal failure, and patients with chronic renal disease. Renal function was measured before dosing and 24 hours and 28 days after oral sulindac. Effective renal plasma flow was reduced in all subjects after 24 hours. Effective renal plasma flow and the glomerular filtration rate were not altered after 28 days in control subjects, whereas effective renal plasma flow, but not glomerular filtration rate, was lower after 1 month in subjects with renal disease. None of these changes are likely to be of major clinical significance.
Clinical Pharmacology and Therapeutics (1985) 37, 298–300; doi:10.1038/clpt.1985.43
28 citations
TL;DR: In this article, the results of thermosolvolysis experiments performed on a high volatile bituminous coal from Yanzhou, China are described, where the coal was preheated in a vacuum at temperatures between 250 and 400 °C, after which the soluble materials were extracted with chloroform, l.r. spectra of the pre-heated coal, and the residue after extraction were measured and compared.
20 citations