P
Peter R. Rapp
Researcher at National Institutes of Health
Publications - 118
Citations - 9223
Peter R. Rapp is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Hippocampus & Hippocampal formation. The author has an hindex of 48, co-authored 109 publications receiving 8513 citations. Previous affiliations of Peter R. Rapp include Salk Institute for Biological Studies & State University of New York System.
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Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.
Peter R. Rapp,Michela Gallagher +1 more
TL;DR: The findings demonstrate that hippocampal neuronal degeneration is not an inevitable consequence of normal aging and that a loss of principal neurons in the hippocampus fails to account for age-related learning and memory impairment.
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Amygdaloid and basal forebrain direct connections with the nucleus of the solitary tract and the dorsal motor nucleus
TL;DR: The existence of such an extensive projection system connecting these specific regions is significant evidence in support to its potential for participation in the amygdaloid expression of cardiovascular influences and has important implications for the cellular analysis of the functional role of these influences.
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The use of animal models to study the effects of aging on cognition
Michela Gallagher,Peter R. Rapp +1 more
TL;DR: The importance of animal models for understanding the effects of normal aging on the brain and cognitive functions and the neurobiological effects of aging that may account for alterations in psychological functions are addressed.
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Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats.
TL;DR: These findings are the first to demonstrate that a circuit-specific pattern of variability in the connectional organization of the hippocampus is coupled to individual differences in the cognitive outcome of normal aging.
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Selective changes in thin spine density and morphology in monkey prefrontal cortex correlate with aging-related cognitive impairment.
Dani Dumitriu,Jiandong Hao,Jiandong Hao,Yuko Hara,Jeffrey Kaufmann,William G.M. Janssen,Wendy Lou,Peter R. Rapp,John H. Morrison +8 more
TL;DR: While both synapse density and the overall spine size average of an animal were predictive of number of trials required for acquisition of DNMS, the strongest correlate of behavior was found to be the head volume of thin spines, with no correlation between behavior and mushroom spine size or density.