Peter S. Bloomfield

TL;DR: There is consistent evidence that a range of psychosocial stressors lead to elevated microglial activity in the hippocampus and good evidence that this is also the case in other brain regions, which is considered in terms of the two-hit hypothesis.

TL;DR: It is suggested that neuroinflammation is linked to the risk of psychosis and related disorders, as well as the expression of subclinical symptoms, in participants at ultra high risk for psychosis.

TL;DR: The main methodological aspects of TSPO PET imaging are reviewed with particular attention to TspO genetics, cellular heterogeneity of T SPO in brain tissue and TSPo distribution in blood and plasma that need to be considered in the quantification of PET data to avoid spurious results as well as ineffective development and use of these radiotracers.

TL;DR: A validation of the kinetic model with the additional endothelial compartment through a displacement study and studied TSPO expression in vessels using 3D reconstructions of histological data of frontal lobe and cerebellum, demonstrating that T SPO positive vessels account for 30% of the vascular volume in cortical and white matter.

TL;DR: Findings suggest that microglial activity is related to the altered cortical volume seen in schizophrenia, and longitudinal investigations are required to determine whether microglia activation leads to cortical gray matter loss.