O
Oliver D. Howes
Researcher at King's College London
Publications - 499
Citations - 29243
Oliver D. Howes is an academic researcher from King's College London. The author has contributed to research in topics: Psychosis & Schizophrenia. The author has an hindex of 75, co-authored 428 publications receiving 21515 citations. Previous affiliations of Oliver D. Howes include NHS England & Medical Research Council.
Papers
More filters
Journal ArticleDOI
The Dopamine Hypothesis of Schizophrenia: Version III—The Final Common Pathway
Oliver D. Howes,Shitij Kapur +1 more
TL;DR: The dopamine hypothesis of schizophrenia-version III is synthesized into a comprehensive framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function.
Journal ArticleDOI
Evidence-based guidelines for treating bipolar disorder: Revised third edition recommendations from the British Association for Psychopharmacology
Guy M. Goodwin,Peter M. Haddad,I. N. Ferrier,Jeffrey K Aronson,T R H Barnes,Andrea Cipriani,David Coghill,Seena Fazel,John R. Geddes,Heinz Grunze,Emily A. Holmes,Oliver D. Howes,S. Hudson,N. Hunt,Ian Jones,Iain Macmillan,H. McAllister-Williams,D. R. Miklowitz,Richard Morriss,Marcus R. Munafò,Carol Paton,B. J. Saharkian,Kate E. A. Saunders,Julia Sinclair,David Taylor,Eduard Vieta,Allan H. Young +26 more
TL;DR: The British Association for Psychopharmacology guidelines specify the scope and targets of treatment for bipolar disorder, and recommend strategies for the use of medicines in short-term treatment of episodes, relapse prevention and stopping treatment.
Journal ArticleDOI
The nature of dopamine dysfunction in schizophrenia and what this means for treatment
Oliver D. Howes,Joseph Kambeitz,Euitae Kim,Daniel Stahl,Mark Slifstein,Anissa Abi-Dargham,Shitij Kapur +6 more
TL;DR: The locus of the largest dopaminergic abnormality in schizophrenia is presynaptic, which affects dopamine synthesis capacity, baseline synaptic dopamine levels, and dopamine release, and future drug development should focus on the control of presYNaptic dopamine synthesis and release capacity.
Journal ArticleDOI
Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia
Oliver D. Howes,Andrew J. Montgomery,M.-C. Asselin,Robin M. Murray,Isabel Valli,Paul Tabraham,Elvira Bramon-Bosch,Lucia Valmaggia,Louise Johns,Matthew R. Broome,Philip McGuire,Paul M. Grasby +11 more
TL;DR: Findings indicate that dopamine overactivity predates the onset of schizophrenia in individuals with prodromal psychotic symptoms, is predominantly localized in the associative striatum, and is correlated with the severity of symptoms and neurocognitive dysfunction.
Journal ArticleDOI
Schizophrenia: an integrated sociodevelopmental-cognitive model
TL;DR: It is shown that developmental alterations secondary to variant genes, early hazards to the brain, and childhood adversity sensitise the dopamine system, and result in excessive presynaptic dopamine synthesis and release.