P
Peter S. Spector
Researcher at University of Vermont
Publications - 56
Citations - 5118
Peter S. Spector is an academic researcher from University of Vermont. The author has contributed to research in topics: Ablation & Catheter ablation. The author has an hindex of 21, co-authored 55 publications receiving 4876 citations. Previous affiliations of Peter S. Spector include University of Oklahoma & University of Utah.
Papers
More filters
Journal ArticleDOI
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Michael C. Sanguinetti,Mark E. Curran,Anruo Zou,Jiaxiang Shen,Peter S. Spector,Donald L. Atkinson,M T Keating +6 more
TL;DR: KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia, and is shown to encode a K+ channel with biophysical properties unlike other known cardiac currents.
Journal ArticleDOI
Treatment of Atrial Fibrillation With Antiarrhythmic Drugs or Radiofrequency Ablation Two Systematic Literature Reviews and Meta-Analyses
Hugh Calkins,Matthew R. Reynolds,Peter S. Spector,Manu Sondhi,Yingxin Xu,Amber Martin,Catherine J. Williams,Isabella Sledge +7 more
TL;DR: In this article, the relative safety and efficacy of radiofrequency catheter ablation (RFA) for atrial fibrillation were evaluated using a randomized clinical trial, and the results showed that RFA is safe and effective.
Journal ArticleDOI
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia
TL;DR: These mutations are predicted to cause a spectrum of diminished IKr and delayed ventricular repolarization, consistent with the prolonged QT interval observed in individuals with LQT.
Journal ArticleDOI
Fast inactivation causes rectification of the IKr channel.
TL;DR: The mechanism of rectification of HERG, the human cardiac delayed rectifier K+ channel, was studied after heterologous expression in Xenopus oocytes, showing voltage-gated fast inactivation and the resulting rectification are partly responsible for the prolonged plateau phase typical of ventricular action potentials.
Journal ArticleDOI
Characterization of Reentrant Circuit in Macroreentrant Right Atrial Tachycardia After Surgical Repair of Congenital Heart Disease Isolated Channels Between Scars Allow “Focal” Ablation
Hiroshi Nakagawa,Nayyar Shah,Kagari Matsudaira,Edward D. Overholt,Krishnaswamy Chandrasekaran,Karen J. Beckman,Peter S. Spector,James Calame,Arun Rao,Can Hasdemir,Kenichiro Otomo,Zulu Wang,Ralph Lazzara,Warren M. Jackman +13 more
TL;DR: The circuit of macroreentrant right atrial tachycardia (MacroAT) in patients after surgical repair of congenital heart disease (SR-CHD) is characterized and ablation within the channel eliminated all 15 MacroATs with 1 to 3 radiofrequency applications.