J
Jiaxiang Shen
Researcher at University of Utah
Publications - 9
Citations - 7503
Jiaxiang Shen is an academic researcher from University of Utah. The author has contributed to research in topics: Sudden death & KCNE2. The author has an hindex of 9, co-authored 9 publications receiving 7255 citations. Previous affiliations of Jiaxiang Shen include Howard Hughes Medical Institute.
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Journal ArticleDOI
Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.
Qing Wang,Mark E. Curran,Igor Splawski,Timothy C. Burn,J. M. Millholland,T. J. VanRaay,Jiaxiang Shen,Katherine W. Timothy,Vincent Gm,Vincent Gm,T. De Jager,Peter J. Schwartz,J.A. Towbin,Arthur J. Moss,Donald L. Atkinson,Gregory M. Landes,Timothy D. Connors,M T Keating +17 more
TL;DR: In this article, positional cloning was used to establish KVLQT1 as the chromosome 11-linked LQT 1 gene responsible for the most common inherited cardiac arrhythmia.
Journal ArticleDOI
Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel.
Michael C. Sanguinetti,Mark E. Curran,Anruo Zou,Jiaxiang Shen,Peter S. Spector,Donald L. Atkinson,M T Keating +6 more
TL;DR: KVLQT1 is the subunit that coassembles with minK to form IKS channels and IKS dysfunction is a cause of cardiac arrhythmia, and is shown to encode a K+ channel with biophysical properties unlike other known cardiac currents.
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SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
Qing Kenneth Wang,Jiaxiang Shen,Jiaxiang Shen,Igor Splawski,Donald L. Atkinson,Donald L. Atkinson,Zhizhong Li,Jennifer L. Robinson,Arthur J. Moss,Jeffrey A. Towbin,Mark T. Keating +10 more
TL;DR: Genetic linkage between LQT3 and polymorphisms within SCN5A, the cardiac sodium channel gene, and single strand conformation polymorphism and DNA sequence analyses suggest that mutations in SCN 5A cause chromosome 3-linked LQt and indicate a likely cellular mechanism for this disorder.
Journal ArticleDOI
Spectrum of Mutations in Long-QT Syndrome Genes KVLQT1, HERG, SCN5A, KCNE1, and KCNE2
Igor Splawski,Jiaxiang Shen,Katherine W. Timothy,Michael H. Lehmann,Silvia G. Priori,Jennifer L. Robinson,Arthur J. Moss,Peter J. Schwartz,Jeffrey A. Towbin,G. Michael Vincent,Mark T. Keating +10 more
TL;DR: KVLQT1 and HERG accounted for 87% of identified mutations, and SCN5A, KCNE1, and KCNE2 accounted for the other 13%, and Missense mutations were most common, followed by frameshift mutations, in-frame deletions, and nonsense and splice-site mutations.
Journal ArticleDOI
Genomic organization of the human SCN5A gene encoding the cardiac sodium channel.
TL;DR: This work establishes the complete genomic organization of SCN5A and will enable high-resolution analyses of this locus for mutations associated with LQT and other phenotypes for which SCN 5A may be a candidate gene.