Peter V. Simpson

TL;DR: The use of metal-based small molecules in chemotherapy is reviewed, focusing on recent studies, and how new nonplatinum-based agents are prompting scientists to increase drug specificity to overcome chemoresistance in cancer cells is discussed.

TL;DR: Five manganese(I) tricarbonyl complexes of the general formula [Mn(CO)3(bpyR,R)(azole)]PF6 with R = H, COOCH3, and azole were synthesized and fully charaterized, including X-ray structure analysis for the ctz compound.

TL;DR: In this article, the Pt-bis N-heterocyclic carbene (NHC) complexes with an ortho-xylyl group were described and structurally and spectroscopically characterised.

TL;DR: Four new N-heterocyclic carbene rhodium and iridium complexes decorated with anionic or cationic pendant groups to increase their water solubility and biological activity have been synthesised and characterised and cellular uptake studies clearly confirmed that the cationIC phosphonium groups facilitated uptake, which was linked with higher biological activity.

TL;DR: An in-depth biological study revealed the origin of the anticancer properties of the rhenium tricarbonyl fragment and found that the ruthenium complexes induce cell cycle arrest at the G2/M phase by inhibiting the phosphorylation of Aurora-A kinase.