P
Peter W. Kalivas
Researcher at Medical University of South Carolina
Publications - 444
Citations - 55913
Peter W. Kalivas is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Nucleus accumbens & Dopamine. The author has an hindex of 123, co-authored 428 publications receiving 52445 citations. Previous affiliations of Peter W. Kalivas include Washington State University & Janssen Pharmaceutica.
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Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.
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Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity
Peter W. Kalivas,Jane Stewart +1 more
TL;DR: It is found that the dopamine neurons of sensitized animals have become increasingly sensitive to excitatory pharmacological and environmental stimuli or desensitized to inhibitory regulation, and changes in cellular activity or protein synthesis may result in a change in the presynaptic regulation of axon terminal dopamine release.
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Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies.
TL;DR: The distinctions between drugs in the induction and expression of sensitization indicate that behavioral sensitization can arise from multiple neuroadaptations in multiple brain nuclei, not only the result of distinct molecular targets for the drugs, but may also include a differential involvement of learned associations.
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A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
TL;DR: The present review examines the literature and critically evaluates the extent to which the neural consequences of repeated psychostimulant administration are associated with the expression of behavioral sensitization.
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Specificity in the projection patterns of accumbal core and shell in the rat.
TL;DR: The efferent projections of the core and shell areas of the nucleus accumbens were studied with a combination of anterograde and retrograde tract-tracing methods, including Phaseolus vulgaris-leucoagglutinin, horseradish peroxidase and fluorescent tracers.