P
Peter Würl
Researcher at University of Ulm
Publications - 38
Citations - 1399
Peter Würl is an academic researcher from University of Ulm. The author has contributed to research in topics: Cancer & Sarcoma. The author has an hindex of 19, co-authored 38 publications receiving 1354 citations. Previous affiliations of Peter Würl include Martin Luther University of Halle-Wittenberg & University of Kiel.
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Journal ArticleDOI
Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma.
Claudia Seidel,Undraga Schagdarsurengin,Karen Blümke,Peter Würl,Gerd P. Pfeifer,Steffen Hauptmann,Helge Taubert,Reinhard Dammann +7 more
TL;DR: The results suggest that alteration of the Sav‐RASSF 1‐Hpo tumor suppressor pathway may occur through hypermethylation of the CpG island promoter of MST1, MST2 and/or RASSF1A in human sarcomas.
Journal ArticleDOI
Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma.
Helge Taubert,Thomas Greither,Deepak Kaushal,Peter Würl,Matthias Bache,Frank Bartel,Astrid Kehlen,C. Lautenschläger,Linda C. Harris,Kai Kraemer,Axel Meye,Matthias Kappler,Hannelore Schmidt,Hans-Jürgen Holzhausen,Steffen Hauptmann +14 more
TL;DR: High-level expression of Hiwi mRNA identifies STS patients at high risk of tumour-related death, the first report showing a correlation between expression of a gene involved in stem cell self-renewal and prognosis of cancer patients.
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The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death
Lukasz-Filip Grochola,Thomas Greither,Helge Taubert,Peter Möller,Uwe Knippschild,A. Udelnow,Doris Henne-Bruns,Peter Würl +7 more
TL;DR: It is suggested that alterations in mRNA expression of Hiwi can increase the risk of tumour-related death in male PDAC patients.
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Knockdown of survivin expression by small interfering RNA reduces the clonogenic survival of human sarcoma cell lines independently of p53
Matthias Kappler,Matthias Bache,Frank Bartel,Matthias Kotzsch,Matti Panian,Peter Würl,Karen Blümke,Hannelore Schmidt,Axel Meye,Helge Taubert,Helge Taubert +10 more
TL;DR: It is suggested that survivin-specific siRNA could be a selective treatment to kill sarcoma cells regardless of the presence or absence of wild-type p53 alleles.
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High prognostic significance of Mdm2/p53 co-overexpression in soft tissue sarcomas of the extremities
Peter Würl,Axel Meye,Hannelore Schmidt,Christine Lautenschläger,Holger Kalthoff,Friedrich-Wilhelm Rath,Helge Taubert +6 more
TL;DR: A high risk sarcoma group has been defined which the authors believe requires alternative therapeutic approaches and coincident Mdm2/p53 overexpression is an independent molecular marker with the highest prognostic relevance described for soft tissue Sarcoma.