P
Petra Högger
Researcher at University of Würzburg
Publications - 83
Citations - 3801
Petra Högger is an academic researcher from University of Würzburg. The author has contributed to research in topics: Glucocorticoid & Receptor. The author has an hindex of 29, co-authored 81 publications receiving 3522 citations. Previous affiliations of Petra Högger include University of Münster & University of California, San Francisco.
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Journal ArticleDOI
Human monocytes express CD163, which is upregulated by IL-10 and identical to p155.
Timothy H. Sulahian,Petra Högger,Andrea E. Wahner,Kathleen Wardwell,Nicolas J. Goulding,Clemens Sorg,Anne Droste,Martin Stehling,Paul K. Wallace,Peter M. Morganelli,Paul M. Guyre +10 more
TL;DR: It is shown that >99% of all CD14 positive monocytes express CD163 and that monocyte derived dendritic cells express low levels of CD163, and that IL-10, like glucocorticoid-inducible member of the scavenger receptor cysteine-rich family of proteins, induces high CD163 expression on cultured human monocytes.
Journal Article
Identification of the Integral Membrane Protein RM3/1 on Human Monocytes as a Glucocorticoid-Inducible Member of the Scavenger Receptor Cysteine-Rich Family (CD163)
TL;DR: It is shown for the first time that CD163 is significantly up-regulated by glucocorticoids, suggesting that it might play an important role in inflammatory processes.
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Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.
TL;DR: It is proposed that a bulky hydrophobic amino acid in the middle of the i2 loop serves as a general site relevant to G protein coupling, whereas coupling selectivity is governed by other receptor domains.
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Regulation of CD 163 on human macrophages: cross-linking of CD163 induces signaling and activation.
M. M. Van Den Heuvel,C. P. Tensen,J. H. Van As,T K van den Berg,D. M. Fluitsma,C. D. Dijkstra,Ed A. Döpp,Anne Droste,F. A. Van Gaalen,Clemens Sorg,Petra Högger,Robert H.J. Beelen +11 more
TL;DR: A function for the SRCR‐superfamily receptor CD163 in the regulation of inflammatory processes by macrophages is suggested, as well as aspects of the tissue distribution, theregulation of expression, and signal transduction after cross‐linking of this receptor at the cell surface of macrophage.
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Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol)
TL;DR: The data contribute to the comprehension of Pycnogenol effects and provide a rational basis for its use in prophylaxis and therapy of disorders related to imbalanced or excessive MMP activity.