P
Petra M. Blix
Researcher at University of Chicago
Publications - 28
Citations - 2659
Petra M. Blix is an academic researcher from University of Chicago. The author has contributed to research in topics: Insulin & C-peptide. The author has an hindex of 22, co-authored 28 publications receiving 2632 citations. Previous affiliations of Petra M. Blix include University of Surrey.
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Journal ArticleDOI
Determination of Free and Total Insulin and C-Peptide in Insulin-treated Diabetics
TL;DR: Clinical studies using this approach indicate that combined measurements of serum free and total insulin and C-peptide provide information that is helpful in understanding the contribution of endogenous and exogenous insulin to the course and metabolic control of insulin-requiring diabetic patients.
Journal ArticleDOI
Characterization of Seven C-peptide Antisera
Ole K. Faber,Christian Binder,J Markussen,L. G. Heding,V K Naithani,Hideshi Kuzuya,Petra M. Blix,David L. Horwitz,Arthur H. Rubenstein +8 more
TL;DR: Differences in C-peptide antisera are a major reason for the variation in the concentration of circulating CPR as measured in different, C- peptide immunoassays.
Journal ArticleDOI
Kinetics of human connecting peptide in normal and diabetic subjects.
O K Faber,Claus Hagen,Chr. Binder,J Markussen,V K Naithani,Petra M. Blix,Hideshi Kuzuya,David L. Horwitz,Arthur H. Rubenstein,N Rossing +9 more
TL;DR: The difference in the half-life of C-peptide in plasma between diabetics and normals suggests an altered kinetics of the disappearance of the peptide, while the overall metabolism, as expressed by the MCR, is similar.
Journal ArticleDOI
Feedback Inhibition of Insulin Secretion by Insulin: Relation to the Hyperinsulinemia of Obesity
Dariush Elahi,M. Nagulesparan,Richard J. Hershcopf,Denis C. Muller,Jordan D. Tobin,Petra M. Blix,Arthur H. Rubenstein,Roger H Unger,Reubin Andres +8 more
TL;DR: Positive short-loop insulin-beta-cell feedback was operative in both the lean and obese states, and despite this suppression, the insulin-secretion rate in obese subjects was still greater than that in non-obese subjects.
Journal ArticleDOI
Three mutant insulins in man
Steven E. Shoelson,M Haneda,Petra M. Blix,A Nanjo,T Sanke,K. Inouye,Donald F. Steiner,Arthur H. Rubenstein,Howard S. Tager +8 more
TL;DR: A method combining HPLC and radioimmunoassay to identify insulin variants isolated from human sera is developed, and it is shown that all three patients noted above secrete structurally variant and chemically distinct insulins.