介绍了Kirk—Othmer Encyclopedia of Chemical Technology（化工技术百科全书）（第五版）电子图书网络版数据库，并对该数据库使用方法和检索途径作出了说明，且结合实例简单地介绍了该数据库的检索方法。

Kirk-Othmer Encyclopedia of Chemical Technology数据库介绍及实例

A new iron(III) halide-promoted aza-Prins cyclization between γ,δ-unsaturated tosylamines and aldehydes provides six-membered azacycles in good to excellent yields. The process is based on the consecutive generation of γ-unsaturated-iminium ion and further nucleophilic attack by the unsaturated carbon−carbon bond. Homoallyl tosylamine leads to trans-2-alkyl-4-halo-1-tosylpiperidine as the major isomer. In addition, the alkyne aza-Prins cyclization between homopropargyl tosylamine and aldehydes gives 2-alkyl-4-halo-1-tosyl-1,2,5,6-tetrahydropyridines as the only cyclic products. The piperidine ring is widely distributed throughout Nature, e.g., in alkaloids,1 and is an important scaffold for drug discovery, being the core of many pharmaceutically significant compounds.2,3 The syntheses of these type of compounds have been extensively studied in the development of new drugs containing six-membered-ring heterocycles.4 Reactions between N-acyliminium ions and nucleophiles, also described as amidoalkylation or Mannich-type condensations, have been frequently used to introduce substituents at the R-carbon of an amine.5 There are several examples that involve an intramolecular attack of a nucleophilic olefin into an iminium cation for the construction of a heterocyclic ring system.6 Traditionally, the use of hemiaminals or their derivatives as precursors of N-acyliminium intermediates has been a common two-step strategy in these reactions.6a Among this type of cyclization is the aza-Prins cyclization,7 which uses alkenes as intramolecular nucleophile. However, cy† X-ray analysis. E-mail address: malopez@ull.es. (1) (a) Fodor, G. B.; Colasanti, B. Alkaloids: Chemical and Biological PerspectiVes; Pelletier, S. W., Ed.; Wiley: New York, 1985; Vol. 23, pp 1-90. (b) Baliah, V.; Jeyarama, R.; Chandrasekaran, L. Chem. ReV. 1983, 83, 379-423. (2) Watson, P. S.; Jiang, B.; Scott, B. Org. Lett. 2000, 2, 3679-3681. (3) Horton, D. A.; Bourne, G. T.; Smythe, M. L. Chem. ReV. 2003, 103, 893-930. (4) Buffat, M. G. P. Tetrahedron 2004, 60, 1701-1729 and references therein. (5) Speckamp, W. N.; Moolenaar, M. J. Tetrahedron 2000, 56, 3187- 3856 and references therein. (6) (a) Hiemstra, H.; Speckamp, W. N. In ComprehensiVe Organic Synthesis; Trost, B. M., Fleming, O., Heathcock, C. H., Eds.; Pergamon: New York, 1991; Vol. 2, pp 1047-1081. (b) Speckamp, W. N.; Hiemstra, H. Tetrahedron 1985, 41, 4367-4416. (7) (a) Dobbs, A. P.; Guesne, S. J. J.; Hursthouse, M. B.; Coles, S. J. Synlett 2003, 11, 1740-1742. (b) Dobbs, A. P.; Guesne, S. J. J.; Martinove, S.; Coles, S. J.; Hursthouse, M. B. J. Org. Chem. 2003, 68, 7880-7883. (c) Hanessian, S.; Tremblay, M.; Petersen, F. W. J. Am. Chem. Soc. 2004, 126, 6064-6071 and references therein. (d) Dobbs, A. P.; Guesne, S. J. Synlett 2005, 13, 2101-2103. ORGANIC

Iron-Catalyzed Reactions in Organic Synthesis

Iron Catalysis in Organic Synthesis

The thermal and physicochemical properties of protic ionic liquids (PILs) are reported. It is highly evident that there has been an extensive range of alkylammonium, imidazolium, and heterocyclic cations paired with many organic and inorganic anions that have been employed to prepare PILs. There has been strong interest in modifying the properties of PILs through the addition of water or other molecular solvents. For many applications, the presence of some water in the PILs is not detrimental, and instead leads to enhanced solvent properties such as lower viscosity, higher conductivities, and lower melting points. It remains an issue of definition though of how to refer to these resulting protic solutions. There is also an ongoing difficulty surrounding how to describe the proton activity in the PILs, analogous to pH in aqueous systems. For a broad range of applications, it has been reported that the acidity/basicity of the PIL or PIL-solvent system is crucial for their beneficial properties. It is expected that the fundamental properties of PILs will continue to be explored, along with continued interest in many existing and new applications, such as in electrochemistry, organic and inorganic synthesis, and biological applications. In particular, there has been a significant interest in a broad- range of PILs for use as electrolytes and incorporation in polymer electrolytes for fuel cells, and other energy storage devices.

Protic Ionic Liquids: Evolving Structure–Property Relationships and Expanding Applications

https://bioone.org/journals/harvard-papers-in-botany/volume-13/issue-2/1043-4534-13.2.299/Flora-of-China/10.3100/1043-4534-13.2.299.pdf

Flora of China

A Novel Synthesis of Macitentan, an Endothelin Receptor Antagonist

Bisdihydroquinazolinones were synthesized for the first time by a novel pseudo five-component condensation of isatoic an- hydride, a primary amine, and a dialdehyde in water. Several sol- vents were examined for this reaction; however, in terms of reaction yield and time, water was found to be the optimum solvent. The ever-increasing demand for novel medicinally active compounds and the laborious process of lead discovery and optimization have resulted in the continuous search for simple and efficient methods for the generation of li- braries for biological screening. 1 Heterocycles are an im- portant class of substrates that are found in natural products and pharmaceuticals. The rigidity of the hetero- cyclic core, which results from the substitution of the core, limits the conformational freedom especially when compared with the corresponding acyclic structure. 2,3- Dihydroquinazolin-4(3H)-ones 1 are a class of heterocy- cles which exhibit biological and pharmaceutical activity as anti-tumor, diuretic, and herbicidal agents, as well as plant growth regulators, and anti-cancer drugs. 2 Also these compounds can be easily oxidized to their quinazo- lin-4(3H)-one analogues, 3 which are among the most im- portant biologically active heterocyclic compounds, 4 and can be found in some natural products. 5

Water‐Accelerated Synthesis of Novel Bis‐2,3‐dihydroquinazolin‐4‐(1H)‐one Derivatives.

Silica Gel Supported γ‐Picolinium Chlorochromate; A New and Efficient Reagent for Selective Conversion of Alcohols and Oximes into Carbonyl Compounds under Mild and Non‐Aqueous Conditions.

An Efficient and Eco‐Friendly Procedure for the Synthesis of Hantzsch Ethyl 1,4‐Dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates under Mild and Green Conditions.

Peyman Salehi

Papers

A Novel Synthesis of Macitentan, an Endothelin Receptor Antagonist

Water‐Accelerated Synthesis of Novel Bis‐2,3‐dihydroquinazolin‐4‐(1H)‐one Derivatives.

Silica Gel Supported γ‐Picolinium Chlorochromate; A New and Efficient Reagent for Selective Conversion of Alcohols and Oximes into Carbonyl Compounds under Mild and Non‐Aqueous Conditions.

An Efficient and Eco‐Friendly Procedure for the Synthesis of Hantzsch Ethyl 1,4‐Dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates under Mild and Green Conditions.

Applications of Some Metal Hydrogen Sulfates in Organic Transformations