P
Phil Quirke
Researcher at University of Leeds
Publications - 97
Citations - 11909
Phil Quirke is an academic researcher from University of Leeds. The author has contributed to research in topics: Colorectal cancer & Total mesorectal excision. The author has an hindex of 37, co-authored 97 publications receiving 10018 citations. Previous affiliations of Phil Quirke include Leeds Teaching Hospitals NHS Trust & Leeds General Infirmary.
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Journal ArticleDOI
Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
David Sebag-Montefiore,Richard Stephens,Robert Steele,John R. T. Monson,Robert Grieve,S. Khanna,Phil Quirke,Jean Couture,Catherine de Metz,Arthur Sun Myint,E M Bessell,Gareth Griffiths,L.C. Thompson,Mahesh K. B. Parmar +13 more
TL;DR: Results from this randomised trial provide convincing and consistent evidence that short-course preoperative radiotherapy is an effective treatment for patients with operable rectal cancer.
Journal ArticleDOI
Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial
Phil Quirke,Phil Quirke,Robert Steele,John R. T. Monson,Robert Grieve,S. Khanna,Jean Couture,Christopher J. O'Callaghan,Arthur Sun Myint,E M Bessell,L.C. Thompson,Mahesh K. B. Parmar,Richard Stephens,David Sebag-Montefiore +13 more
TL;DR: In rectal cancer, the plane of surgery achieved is an important prognostic factor for local recurrence, and both a negative circumferential resection margin and a superior plane of Surgery achieved were associated with lowLocal recurrence rates.
Journal ArticleDOI
What Is the Role for the Circumferential Margin in the Modern Treatment of Rectal Cancer
Iris D. Nagtegaal,Phil Quirke +1 more
TL;DR: It is demonstrated that, after neoadjuvant therapy (both radiotherapy and radiochemotherapy), the predictive value of the CRM for local recurrence is significantly higher than when no preoperative therapy has been applied and involvement is one of the key factors in rectal cancer treatment.
Journal ArticleDOI
Macroscopic Evaluation of Rectal Cancer Resection Specimen: Clinical Significance of the Pathologist in Quality Control
Iris D. Nagtegaal,Cornelis J.H. van de Velde,Erik van der Worp,Ellen Kapiteijn,Phil Quirke,J. Han van Krieken +5 more
TL;DR: Criteria by which pathologists can judge the quality or completeness of the resection specimen in a randomized trial for rectal cancer is evaluated and a new role of the pathologist in quality control is established.
Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study
Gina Brown,Ian R. Daniels,Richard J. Heald,Phil Quirke,Lennart Blomqvist,David Sebag-Montefiore,Brendan J. Moran,Torbjörn Holm,J Strassbourg,P. D Peppercorn,S. E. Fisher,B Mason,Mercury Study Grp +12 more
TL;DR: This technique can be reproduced accurately in multiple centres to predict curative resection and warns the multidisciplinary team of potential failure of surgery, thus enabling selection of patients for preoperative treatment.