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David Sebag-Montefiore
Researcher at University of Leeds
Publications - 226
Citations - 13725
David Sebag-Montefiore is an academic researcher from University of Leeds. The author has contributed to research in topics: Chemoradiotherapy & Radiation therapy. The author has an hindex of 46, co-authored 212 publications receiving 11392 citations. Previous affiliations of David Sebag-Montefiore include Mount Vernon Hospital & St Bartholomew's Hospital.
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Journal ArticleDOI
Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial
David Sebag-Montefiore,Richard Stephens,Robert Steele,John R. T. Monson,Robert Grieve,S. Khanna,Phil Quirke,Jean Couture,Catherine de Metz,Arthur Sun Myint,E M Bessell,Gareth Griffiths,L.C. Thompson,Mahesh K. B. Parmar +13 more
TL;DR: Results from this randomised trial provide convincing and consistent evidence that short-course preoperative radiotherapy is an effective treatment for patients with operable rectal cancer.
Journal ArticleDOI
Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial
Phil Quirke,Phil Quirke,Robert Steele,John R. T. Monson,Robert Grieve,S. Khanna,Jean Couture,Christopher J. O'Callaghan,Arthur Sun Myint,E M Bessell,L.C. Thompson,Mahesh K. B. Parmar,Richard Stephens,David Sebag-Montefiore +13 more
TL;DR: In rectal cancer, the plane of surgery achieved is an important prognostic factor for local recurrence, and both a negative circumferential resection margin and a superior plane of Surgery achieved were associated with lowLocal recurrence rates.
Diagnostic accuracy of preoperative magnetic resonance imaging in predicting curative resection of rectal cancer: prospective observational study
Gina Brown,Ian R. Daniels,Richard J. Heald,Phil Quirke,Lennart Blomqvist,David Sebag-Montefiore,Brendan J. Moran,Torbjörn Holm,J Strassbourg,P. D Peppercorn,S. E. Fisher,B Mason,Mercury Study Grp +12 more
TL;DR: This technique can be reproduced accurately in multiple centres to predict curative resection and warns the multidisciplinary team of potential failure of surgery, thus enabling selection of patients for preoperative treatment.
Journal ArticleDOI
Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2×2 factorial trial
Roger D James,Rob Glynne-Jones,Helen Meadows,David Cunningham,Arthur Sun Myint,Mark P Saunders,Tim Maughan,Alec McDonald,Sharadah Essapen,Martin Leslie,Stephen Falk,Charles Wilson,Simon Gollins,Rubina Begum,Jonathan A. Ledermann,Latha Kadalayil,David Sebag-Montefiore +16 more
TL;DR: The results of this trial--the largest in anal cancer to date--show that fluorouracil and mitomycin with 50.4 Gy radiotherapy in 28 daily fractions should remain standard practice in the UK.
Journal ArticleDOI
Magnetic Resonance Imaging–Detected Tumor Response for Locally Advanced Rectal Cancer Predicts Survival Outcomes: MERCURY Experience
Uday B. Patel,Fiona Taylor,Lennart Blomqvist,Christopher George,Hywel Evans,Paris P. Tekkis,Philip Quirke,David Sebag-Montefiore,Brendan Moran,Richard J. Heald,Ashley Guthrie,N Bees,Ian Swift,Kjell Pennert,Gina Brown +14 more
TL;DR: MRI assessment of TRG and CRM are imaging markers that predict survival outcomes for good and poor responders and provide an opportunity for the multidisciplinary team to offer additional treatment options before planning definitive surgery.