P
Philip A. Ludbrook
Researcher at Washington University in St. Louis
Publications - 111
Citations - 5941
Philip A. Ludbrook is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Diastole & Myocardial infarction. The author has an hindex of 35, co-authored 111 publications receiving 5815 citations. Previous affiliations of Philip A. Ludbrook include University of California, San Diego.
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Journal ArticleDOI
Nephrotoxicity of ionic and nonionic contrast media in 1196 patients: A randomized trial
Michael R. Rudnick,Stanley Goldfarb,Lewis Wexler,Philip A. Ludbrook,Mary J. Murphy,Elkan F. Halpern,James A. Hill,Michael D. Winniford,Martin B. Cohen,Douglas B. VanFossen +9 more
TL;DR: In patients undergoing cardiac angiography, only those with pre-existing RI alone or combined with DM are at higher risk for acute contrast nephrotoxicity, according to a multivariate analysis.
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Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.
Desire Collen,Eric J. Topol,A J Tiefenbrunn,Herman K. Gold,Myron L. Weisfeldt,Burton E. Sobel,Robert C. Leinbach,Jeffrey A. Brinker,Philip A. Ludbrook,I Yasuda +9 more
TL;DR: Either intravenous or intracoronary rt-PA induced coronary thrombolysis without eliciting clinically significant fibrinogenolysis in patients with evolving myocardial infarction due to thrombotic coronary occlusion is reported.
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Transmitral pressure-flow velocity relation. Importance of regional pressure gradients in the left ventricle during diastole.
TL;DR: Effects of regional diastolic pressure differences within the left ventricle on the measured transmitral pressure-flow relation were determined by simultaneous micromanometric left atrial and left ventricular pressure measurements, and Doppler echocardiograms in 11 anesthetized, closed-chest dogs.
Journal ArticleDOI
Coronary thrombolysis with tissue-type plasminogen activator in patients with evolving myocardial infarction.
F. Van de Werf,Philip A. Ludbrook,Steven R. Bergmann,Alan J. Tiefenbrunn,Keith A.A. Fox,H De Geest,M. Verstraete,Desire Collen,Burton E. Sobel +8 more
TL;DR: Observations indicate that clot-selective coronary thrombolysis can be induced in patients with evolving myocardial infarction by means of tissue-type plasminogen activator, without concomitant induction of a systemic lytic state.
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Specificity of elevated serum MB creatine phosphokinase activity in the diagnosis of acute myocardial infarction
TL;DR: Elevated serum MB CPK activity is a highly specific as well as sensitive criterion of myocardial injury.