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Philip C. Burcham
Researcher at University of Western Australia
Publications - 77
Citations - 3145
Philip C. Burcham is an academic researcher from University of Western Australia. The author has contributed to research in topics: Acrolein & DNA damage. The author has an hindex of 26, co-authored 76 publications receiving 2991 citations. Previous affiliations of Philip C. Burcham include University of Adelaide.
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Endogenous DNA adducts: potential and paradox
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Genotoxic lipid peroxidation products : their DNA damaging properties and role in formation of endogenous DNA adducts
TL;DR: This review surveys the genotoxic properties of the major classes of lipid peroxidation products, focusing on their chemistry of DNA adduction, the mutagenic properties of such damage and the evidence that it occurs in intact biological systems.
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Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes
Suzanne Froscio,Andrew R. Humpage,Andrew R. Humpage,Philip C. Burcham,Ian R. Falconer,Ian R. Falconer +5 more
TL;DR: The total abolition of protein synthesis may exaggerate the metabolite effects but cannot be considered a primary cause of cell death in hepatocytes over an acute time frame, and in cell types deficient in CYP450 enzymes, protein synthesis inhibition may play a more crucial role in the development of cytotoxicity.
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Acetaminophen Toxicity Results in Site-specific Mitochondrial Damage in Isolated Mouse Hepatocytes*
TL;DR: The results indicate that a loss of the ability to utilize succinate- and NADH-linked substrates due to attack of the respiratory chain by NAPQI causes a disruption of energy homeostasis in acetaminophen hepatotoxicity.
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Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress.
TL;DR: In this paper, the authors quantified the process in primary mouse hepatocytes using the COMET assay in both the presence and absence of CYP450 inhibitors known to block acute CYN cytotoxicity.