P
Philip Coish
Researcher at Yale University
Publications - 45
Citations - 1475
Philip Coish is an academic researcher from Yale University. The author has contributed to research in topics: Transmetalation & Stille reaction. The author has an hindex of 18, co-authored 45 publications receiving 1153 citations. Previous affiliations of Philip Coish include Bayer Corporation & University of Pittsburgh.
Papers
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Journal ArticleDOI
The Green ChemisTREE: 20 years after taking root with the 12 principles
Hanno C. Erythropel,Julie B. Zimmerman,Tamara M. de Winter,Laurène Petitjean,Fjodor Melnikov,Chun Ho Lam,A.W. Lounsbury,Karolina E. Mellor,Nina Z. Janković,Qingshi Tu,Lauren N. Pincus,Mark M. Falinski,Wenbo Shi,Philip Coish,Desiree L. Plata,Paul T. Anastas +15 more
TL;DR: The Green ChemisTrees as discussed by the authors is a showcase for the diversity of research and achievements stemming from green chemistry, inspired by tree diagrams that illustrate diversity of products stemming from raw materials.
Journal ArticleDOI
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Joachim Rudolph,William P. Esler,Stephen O'connor,Philip Coish,Philip Wickens,Michael Brands,Donald Bierer,Brian T. Bloomquist,Georgiy Bondar,Libing Chen,Chih-Yuan Chuang,Thomas H. Claus,Zahra Fathi,Wenlang Fu,Uday Khire,James A. Kristie,Xiao-Gao Liu,Derek B. Lowe,Andrea Mcclure,Martin Michels,Astrid A. Ortiz,Philip D. Ramsden,Robert Schoenleber,Tatiana E. Shelekhin,Alexandros Vakalopoulos,Weifeng Tang,Lei Wang,Lin Yi,Stephen J. Gardell,James N. Livingston,Laurel Sweet,Bullock William H +31 more
TL;DR: Piperidine-substituted quinazolinone derivatives were identified as a new class of small-molecule GHS-R1a antagonists and revealed suppression of food intake and body weight reduction as well as glucose-lowering effects mediated by glucose-dependent insulin secretion.
Patent
Preparation and use of aryl alkyl acid derivatives for the treatment of obesity
Roger A. Smith,Ann-Marie Campbell,Philip Coish,Miao Dai,Susan Jenkins,Derek B. Lowe,Stephen J. O'connor,Ning Su,Gan Wang,Mingbao Zhang,Lei Zhu +10 more
TL;DR: In this article, aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases are described. But they do not discuss the use of these compounds in medical applications.
Journal ArticleDOI
Cradle-to-Gate Greenhouse Gas Emissions for TwentyAnesthetic Active Pharmaceutical Ingredients Based on Process Scale-Upand Process Design Calculations
Abhijeet G. Parvatker,Huseyin Tunceroglu,Jodi D. Sherman,Philip Coish,Paul T. Anastas,Julie B. Zimmerman,Matthew J. Eckelman +6 more
TL;DR: This study uses chemical engineering methods for process scale-up and process design to utilize lab-scale synthesis data, available in patents and other public literature, to generate cradle-to-gate LCI data of 20 commonly used injectable drugs in anesthesia care to calculate their greenhouse gas impact.
Journal ArticleDOI
Small molecule inhibitors of IKK kinase activity
TL;DR: This paper reviews the patenting activity associated with small molecule inhibitors of κB kinase complex in the activation of NF-κB and examines its role in the pathogenesis of a variety of diseases.