P
Philip J. Reeves
Researcher at University of Essex
Publications - 78
Citations - 5151
Philip J. Reeves is an academic researcher from University of Essex. The author has contributed to research in topics: Rhodopsin & G protein-coupled receptor. The author has an hindex of 35, co-authored 75 publications receiving 4713 citations. Previous affiliations of Philip J. Reeves include University of Pittsburgh & University of Warwick.
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Structure and function in rhodopsin: High-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line
TL;DR: The toxic constitutively active rhodopsin mutant, E113Q/E134Q/M257Y, previously shown to require inducible expression, has now been expressed in an HEK293S GNTI−-inducible cell line at levels comparable with those obtained with WT rhodopin.
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The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa.
S. Jones,B. Yu,N. J. Bainton,M. Birdsall,Barrie W. Bycroft,S. R. Chhabra,A. J. R. Cox,P. Golby,Philip J. Reeves,S. Stephens +9 more
TL;DR: HSL has now been linked to the control of bioluminescence in Vibrio fischeri, carbapenem antibiotic production of E.carotovora and the above exoenzyme virulence determinants, which significantly enhances the understanding of the extent and nature of pheromone mediated gene expression control in prokaryotes.
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Membrane traffic wardens and protein secretion in gram-negative bacteria.
TL;DR: It is suggested that a third (Type III) secretory pathway exists in which protein secretion is signal sequence-independent and via the periplasm.
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A novel strategy for the isolation of luxI homologues : evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria
Simon Swift,Michael K. Winson,P. F. Chan,Nigel J. Bainton,M. Birdsall,Philip J. Reeves,Catherine E. D. Rees,Siri Ram Chhabra,Philip J. Hill,John P. Throup,Barrie W. Bycroft,George P. C. Salmond,Paul Williams,G. S. A. B. Stewart +13 more
TL;DR: Using a lux plasmid‐based bioluminescent sensor for OHHL, pheromone production by E. carotovora, Enterobacter agglomerans, Hafnia alvei, Rahnella aquatilis and Serratia marcescens has been demonstrated and shown also to be cell density‐dependent.
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The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy
Dimitra Athanasiou,Mònica Aguilà,James Bellingham,Wenwen Li,Caroline McCulley,Philip J. Reeves,Michael E. Cheetham +6 more
TL;DR: Rhodopsin adRP offers a unique paradigm to understand how disturbances in photoreceptor homeostasis can lead to neuronal cell death, with defects ranging from misfolding and disruption of proteostasis, through mislocalisation and disrupted intracellular traffic to instability and altered function.