M
Michael K. Winson
Researcher at Aberystwyth University
Publications - 43
Citations - 7663
Michael K. Winson is an academic researcher from Aberystwyth University. The author has contributed to research in topics: Quorum sensing & Homoserine. The author has an hindex of 27, co-authored 43 publications receiving 7350 citations. Previous affiliations of Michael K. Winson include University of Wales & University of Nottingham.
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Journal ArticleDOI
Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones
Kay H. McClean,Michael K. Winson,Leigh Fish,Adrian Taylor,Siri Ram Chhabra,Miguel Cámara,Mavis Daykin,John H. Lamb,Simon Swift,Barrie W. Bycroft,Gordon S. A. B. Stewart,Paul Williams +11 more
TL;DR: The ability of CV026 to respond to a series of synthetic AHL and N-acylhomocysteine thiolactone (AHT) analogues is explored, greatly extending the ability to detect a wide spectrum of AHL signal molecules.
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Systematic functional analysis of the yeast genome
TL;DR: The genome sequence of the yeast Saccharomyces cerevisiae has provided the first complete inventory of the working parts of a eukaryotic cell, and systematic and comprehensive approaches to the elucidation of yeast gene function are discussed.
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Construction and analysis of luxCDABE-based plasmid sensors for investigating N-acyl homoserine lactone-mediated quorum sensing
Michael K. Winson,Simon Swift,Leigh Fish,John P. Throup,Frieda Jørgensen,Siri Ram Chhabra,Barrie W. Bycroft,Paul Williams,Gordon S. A. B. Stewart +8 more
TL;DR: Plasmid reporter vectors have been constructed which respond to activation of LuxR and its homologues LasR and RhlR by N-acyl homoserine lactones by AHLs, allowing a comprehensive evaluation of quorum sensing signals from a test organism.
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Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa
Michael K. Winson,Miguel Cámara,Amel Latifi,Maryline Foglino,Siri Ram Chhabra,Mavis Daykin,Marc Bally,Virginie Chapon,George P. C. Salmond,Barrie W. Bycroft +9 more
TL;DR: Using HPLC, mass spectrometry, and NMR spectroscopy, it is established that in Escherichia coli, VsmI directs the synthesis of N-butanoyl-L-homoserine lactone (BHL) and N-hexanoyL- L-homologically-based lactones (HHL).
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Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
Amel Latifi,Michael K. Winson,Maryline Foglino,Barrie W. Bycroft,Gordon S. A. B. Stewart,Andrée Lazdunski,Paul Williams +6 more
TL;DR: PAN067 is also defective in the production of alkaline protease, haemolysin, cyanide, pyocyanin and autoinducer(s), providing clear evidence that multiple families of quorum‐sensing modulons interactively regulate gene expression in P. aeruginosa.