P
Philip W. Garrett-engele
Researcher at Merck & Co.
Publications - 29
Citations - 12949
Philip W. Garrett-engele is an academic researcher from Merck & Co.. The author has contributed to research in topics: Gene & Polynucleotide. The author has an hindex of 18, co-authored 29 publications receiving 12352 citations. Previous affiliations of Philip W. Garrett-engele include Life Technologies.
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Journal ArticleDOI
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
Lee P. Lim,Nelson C. Lau,Philip W. Garrett-engele,Andrew Grimson,Janell M. Schelter,John C. Castle,David P. Bartel,Peter S. Linsley,Jason M. Johnson +8 more
TL;DR: These results suggest that metazoan miRNAs can reduce the levels of many of their target transcripts, not just the amount of protein deriving from these transcripts, and seem to downregulate a far greater number of targets than previously appreciated.
Journal ArticleDOI
MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
Andrew Grimson,Kyle Kai-How Farh,Wendy K. Johnston,Philip W. Garrett-engele,Lee P. Lim,David P. Bartel +5 more
TL;DR: Five general features of site context that boost site efficacy are uncovered: AU-rich nucleotide composition near the site, proximity to sites for coexpressed miRNAs (which leads to cooperative action), proximity to residues pairing to miRNA nucleotides 13-16, positioning within the 3'UTR at least 15 nt from the stop codon, and positioning away from the center of long UTRs.
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Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.
Jason M. Johnson,John C. Castle,Philip W. Garrett-engele,Zhengyan Kan,Patrick M. Loerch,Christopher D. Armour,Ralph Santos,Eric E. Schadt,Roland Stoughton,Daniel D. Shoemaker +9 more
TL;DR: These genome-wide data provide experimental evidence and tissue distributions for thousands of known and novel alternative splicing events and indicate that at least 74% of human multi-exon genes are alternatively spliced.
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Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury
Omar F Laterza,Lee Lim,Philip W. Garrett-engele,Katerina Vlasakova,Nagaraja Muniappa,Wesley Tanaka,Jason M. Johnson,Joseph F. Sina,Thomas L. Fare,Frank D. Sistare,Warren E. Glaab +10 more
TL;DR: These results demonstrate that tissue-specific miRNAs may serve as diagnostically sensitive plasma biomarkers of tissue injury.
Journal ArticleDOI
A quantitative atlas of polyadenylation in five mammals
Adnan Derti,Philip W. Garrett-engele,Kenzie D. MacIsaac,Richard C. Stevens,Shreedharan Sriram,Ronghua Chen,Carol A. Rohl,Jason M. Johnson,Tomas Babak +8 more
TL;DR: PolyA-seq is shown to be as accurate as existing RNA sequencing approaches for digital gene expression (DGE), enabling simultaneous mapping of polyA sites and quantitative measurement of their usage, and usage is more similar within the same tissues across different species than within a species.