Christopher D. Armour

TL;DR: A reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae is constructed, and it is shown that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles.

TL;DR: These genome-wide data provide experimental evidence and tissue distributions for thousands of known and novel alternative splicing events and indicate that at least 74% of human multi-exon genes are alternatively spliced.

TL;DR: Using ‘exon’ and ‘tiling’ arrays fabricated by ink-jet oligonucleotide synthesis, an experimental approach is devised to validate and refine computational gene predictions and define full-length transcripts on the basis of co-regulated expression of their exons.

TL;DR: A genome-wide pool of tagged heterozygotes was used to assess the cellular effects of 78 compounds in Saccharomyces cerevisiae, and lanosterol synthase in the sterol biosynthetic pathway was identified as a target of the antianginal drug molsidomine, which may explain its cholesterol-lowering effects.

TL;DR: Using next-generation sequencing, a whole-transcriptome analysis of the host response to severe acute respiratory syndrome coronavirus infection across four founder mouse strains of the Collaborative Cross demonstrated that virus infection alters the expression of numerous long ncRNAs, suggesting that these RNAs may be a new class of regulatory molecules that play a role in determining the outcome of infection.