P
Philippe Bisel
Researcher at University of Freiburg
Publications - 32
Citations - 604
Philippe Bisel is an academic researcher from University of Freiburg. The author has contributed to research in topics: Enantioselective synthesis & Strecker amino acid synthesis. The author has an hindex of 14, co-authored 31 publications receiving 530 citations.
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Characterization of the designer benzodiazepine diclazepam and preliminary data on its metabolism and pharmacokinetics.
TL;DR: Based on this study, diclazepam has an approximate elimination half-life of 42 h and is metabolized into the pharmacologically active benzodiazepines delorazepAm, lorazEPam, and lormetazep am which can be detected in urine for 6, 19, and 11 days, respectively, when applying the presented LC-MS/MS method.
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Characterization of the four designer benzodiazepines clonazolam, deschloroetizolam, flubromazolam, and meclonazepam, and identification of their in vitro metabolites
Laura M. Huppertz,Philippe Bisel,Folker Westphal,Florian Franz,Volker Auwärter,Bjoern Moosmann +5 more
TL;DR: The characterization of these four designer benzodiazepines using nuclear magnetic resonance spectroscopy, gas chromatography–electron ionization-mass spectrometry, liquid chromatography-tandem mass spectrometric, liquid Chromatography–quadrupole time-of-flight-massSpectroscopy and infrared spectroscopic is presented.
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The tert-butyl group in chemistry and biology.
TL;DR: The unique reactivity pattern elicited by the crowded tert-butyl group is highlighted by summarising characteristic applications and the way through to its possible application in biocatalytic processes is described.
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Identification of the cannabimimetic AM-1220 and its azepane isomer ( N -methylazepan-3-yl)-3-(1-naphthoyl)indole in a research chemical and several herbal mixtures
Stefan Kneisel,Philippe Bisel,Volker Brecht,Sebastian Broecker,Michael Müller,Volker Auwärter +5 more
TL;DR: In this article, high-resolution mass spectroscopy (HR-MS) revealed an elemental composition of C26H26N2O for both substances, proving the presence of two isobaric substances, and GC-MS and LC-HRMS/MS experiments indicated two naphthoylindoles featuring different heterocyclic substituents at the indole nitrogen.
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Identification and structural characterization of the synthetic cannabinoid 3-(1-adamantoyl)-1-pentylindole as an additive in ‘herbal incense’
Stefan Kneisel,Folker Westphal,Philippe Bisel,Volker Brecht,Sebastian Broecker,Volker Auwärter +5 more
TL;DR: The identification of a new--and due to its substitution pattern rather uncommon--cannabimimetic found in several 'herbal incense' products supports that the listing of synthetic cannabinoids as prohibited substances triggers the appearance of compounds with uncommon substituents.