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Pierre-Emmanuel Puig
Researcher at French Institute of Health and Medical Research
Publications - 5
Citations - 1455
Pierre-Emmanuel Puig is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Apoptosis. The author has an hindex of 4, co-authored 5 publications receiving 1217 citations.
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Journal ArticleDOI
Mechanisms of cytochrome c release from mitochondria
Carmen Garrido,Lorenzo Galluzzi,Mathilde Brunet,Pierre-Emmanuel Puig,Celine Didelot,Guido Kroemer +5 more
TL;DR: Cyt c has been associated also to vital cell functions (i.e. differentiation), suggesting that its release not always occurs in an all-or-nothing fashion and that mitochondrial outer membrane permeabilization may not invariably lead to cell death.
Journal ArticleDOI
Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy.
Pierre-Emmanuel Puig,Marie-Noëlle Guilly,André Bouchot,Nathalie Droin,Nathalie Droin,Dominique Cathelin,Dominique Cathelin,Florence Bouyer,Florence Bouyer,Laure Favier,François Ghiringhelli,François Ghiringhelli,Guido Kroemer,Eric Solary,Eric Solary,François Martin,François Martin,Bruno Chauffert,Bruno Chauffert +18 more
TL;DR: Assessment of in vivo and in vitro data suggest that a multistep pathway, including DNA endoreduplication, polyploidy, then depolyploidization and generation of clonogenic escape cells can account for tumor relapse after initial efficient chemotherapy.
Journal ArticleDOI
Heat shock protein 70 neutralization exerts potent antitumor effects in animal models of colon cancer and melanoma.
Elise Schmitt,Loic Maingret,Pierre-Emmanuel Puig,Anne-Laure Rérole,François Ghiringhelli,Arlette Hammann,Eric Solary,Guido Kroemer,Carmen Garrido +8 more
TL;DR: It is shown that expression of ADD70 in tumor cells decreases their tumorigenicity in syngeneic animals without affecting their growth in immunodeficient animals, indicating the potential interest of targeting the HSP70 interaction with AIF for cancer therapy.
Journal ArticleDOI
DNA-damaged polyploid cancer cells can reverse to diploidy: an ordered, but little understood, process of genomic reduction [with reference to the previous comments of Forer (2008) and Wheatley (2008a and b)].
TL;DR: It is shown that the diploid, proliferating ‘‘escape cells’’ originated from the polyploid giant cells resulting from DNA endoreduplication, not from a small proportion of cells that may have survived damage while maintaining their diploidsy (or possible pseudodiploid aneuploidy) following DNA damage.