F
François Martin
Researcher at French Institute of Health and Medical Research
Publications - 141
Citations - 13343
François Martin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 46, co-authored 135 publications receiving 12429 citations. Previous affiliations of François Martin include University of Burgundy & Centre national de la recherche scientifique.
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Journal ArticleDOI
Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
François Ghiringhelli,Cédric Ménard,Pierre Emmanuel Puig,Sylvain Ladoire,Stephan Roux,François Martin,Eric Solary,Axel Le Cesne,Laurence Zitvogel,Bruno Chauffert +9 more
TL;DR: Oral administration of metronomic cyclophosphamide in advanced cancer patients induces a profound and selective reduction of circulating regulatory T cells, associated with a suppression of their inhibitory functions on conventional T cells and NK cells leading to a restoration of peripheral T cell proliferation and innate killing activities.
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5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity
Julie Vincent,Grégoire Mignot,Fanny Chalmin,Sylvain Ladoire,Mélanie Bruchard,Angélique Chevriaux,François Martin,Lionel Apetoh,Cédric Rébé,François Ghiringhelli +9 more
TL;DR: Findings suggest that the antitumor effect of 5FU is mediated, at least in part, by its selective cytotoxic action on MDSC.
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CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
François Ghiringhelli,Nicolas Larmonier,Elise Schmitt,Arnaud Parcellier,Dominique Cathelin,Carmen Garrido,Bruno Chauffert,Eric Solary,Bernard Bonnotte,François Martin +9 more
TL;DR: In this paper, the authors investigated the mechanisms of immune tolerance raised by tumors by comparing immunogenic and tolerogenic tumor cell clones isolated from a rat colon carcinoma, and showed that PROb tumor volume is correlated with an expansion of CD4(+)CD25(+) regulatory T lymphocytes in lymphoid tissues.
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CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner
François Ghiringhelli,Cédric Ménard,Magali Terme,Caroline Flament,Julien Taieb,Nathalie Chaput,Pierre E. Puig,Sophie Novault,Bernard Escudier,Eric Vivier,A. Lecesne,Caroline Robert,Jean-Yves Blay,Jacky Bernard,Sophie Caillat-Zucman,Antônio C. Freitas,T. Tursz,Orianne Wagner-Ballon,Claude Capron,William Vainchencker,François Martin,Laurence Zitvogel +21 more
TL;DR: A role for T reg cells in blunting the NK cell arm of the innate immune system is supported in controlling innate antitumor immunity through inhibition of NK cell effector functions and down-regulated NKG2D receptors on theNK cell surface.
Journal ArticleDOI
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
Fanny Chalmin,Sylvain Ladoire,Grégoire Mignot,Julie Vincent,Mélanie Bruchard,Jean-Paul Remy-Martin,Wilfrid Boireau,Alain Rouleau,Benoit Simon,David Lanneau,Aurélie de Thonel,Gabriele Multhoff,Arlette Hamman,François Martin,Bruno Chauffert,Eric Solary,Laurence Zitvogel,Carmen Garrido,Bernhard Ryffel,Christophe Borg,Lionel Apetoh,Cédric Rébé,François Ghiringhelli +22 more
TL;DR: It is shown in both mice and humans that Hsp72 expressed at the surface of TDEs restrains tumor immune surveillance by promoting MDSC suppressive functions.