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Pierre L. Beaulieu
Researcher at Boehringer Ingelheim
Publications - 135
Citations - 4781
Pierre L. Beaulieu is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Hepatitis C virus & Polymerase. The author has an hindex of 36, co-authored 133 publications receiving 4640 citations.
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Patent
Condensed triclyclic compounds as inhibitors of hiv replication
Claudio Sturino,Pierre L. Beaulieu,Patrick Deroy,Martin Duplessis,Clint James,Jean-Eric Lacoste,Joannie Minville,Louis Morency,Sébastien Morin,Bruno Simoneau,Martin Tremblay +10 more
TL;DR: In this article, the authors proposed an inbitor of HIV replication using a combination of formula (I) and pharmaceutical compositions thereof, where A 1 A 2 and A 3 are each independently selected from the group consisting of N and CR 3, wherein R 1 is an optionally substituted heterocyclyl or an optionally substituting -(C 1-6 )alkyl-heterocycyll, R 2 is an alternatively substituted aryl or a optionally subsisted heteroaryl, R 4 is a optionally substituted ayl, and R 5 is an an
Journal ArticleDOI
Synthesis of ketones by cyclization of cyano and acetylenic radicals: use of .delta.-hydroxy nitriles and .delta.- or .epsilon.-hydroxy acetylenes
TL;DR: Le radical intermediaire genere par desoxygenation d'alcools peut operer une cyclisation intramoleculaire quand des liaisons C≡C et c≡N sont presentes.
Journal ArticleDOI
Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements.
Pierre L. Beaulieu,Dale R. Cameron,Jean-Marie Ferland,Jean Gauthier,Ghiro Elise,James Gillard,Vida Gorys,Martin Poirier,Jean Rancourt,Dominik Wernic,Montse Llinas-Brunet,Raj Betageri,Mario G. Cardozo,Eugene R. Hickey,Richard H. Ingraham,Scott Jakes,Alisa K. Kabcenell,Kirrane Thomas M,Susan Lukas,Usha R. Patel,John R. Proudfoot,Rajiv Sharma,Liang Tong,Neil Moss +23 more
TL;DR: The discovery of potent (2-3 microM), hydrolytically stable dipeptide derivatives, bearing only two charges at physiological pH, represents a significant step toward the discovery of compounds with cellular activity and the development of novel therapeutics for conditions associated with undesired T-cell proliferation.
Journal ArticleDOI
Preparation of (2S,4R)-4-Hydroxypipecolic Acid and Derivatives
James Gillard,A. Abraham,Paul C. Anderson,Pierre L. Beaulieu,Tibor Bogri,Yves Bousquet,Louis Grenier,and Ingrid Guse,Pierre Lavallee +8 more
Journal ArticleDOI
Large scale preparation of (2S,3S)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane: A key building block for HIV-protease inhibitors
TL;DR: In this article, the synthesis of (2S,3S)-N-Boc-3amino-1,2-epoxy-4-phenylbutane is described.