Publisher Summary This chapter discusses prostaglandins and thromboxanes. The prostaglandins are C 20 acids formed from polyunsaturated fatty acids by oxygenation and cyclization. The thromboxanes, which were originally found in platelets, have now been identified in a variety of tissues. Rapid progress is being made in understanding their biological roles. Earlier studies on vascular and airway smooth muscle demonstrated that endoperoxides had unique effects that could not be attributed to conversion into the stable prostaglandins. Because aspirin, an inhibitor of endoperoxide formation, inhibits the second wave of aggregation, it was suggested that the endoperoxides play a role in the release reaction. The potency of the endoperoxides in causing contractions of the isolated rabbit aorta was of particular interest. However, the occurrence of thromboxanes is not limited to platelets. The transformation of arachidonic acid into thromboxane B 2 has also been observed in lung tissue, spleen, kidney, leukocytes, umbilical artery, and brain.

Prostaglandins and thromboxanes.

Protease inhibitors: current status and future prospects.

https://www.bgu.ac.il/~meijler/literature/peptide_synth.pdf

Recent development of peptide coupling reagents in organic synthesis

Large-scale oxidations in the pharmaceutical industry.

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

The utility of tert-butyldiphenylsilyl chloride as a reagent for the protection of hydroxyl groups was explored. The corresponding tert-BDPSi ethers have much greater stability to acids, and under ...

The Preparation and Synthetic Utility of tert-Butyldiphenylsilyl Ethers

A stereospecific, total synthesis of crystalline thromboxane B2 from D-glucose is described.

A stereospecifie, total synthesis of thromboxane B2

Palinavir is a potent peptidomimetic-based HIV protease inhibitor. We have developed a highly convergent and stereoselective synthesis which is amenable to the preparation of multikilogram quantities of this compound. The synthetic sequence proceeds in 24 distinct chemical steps (with several integrated, multistep operations) from commercially available starting materials. No chromatographies are required throughout the process, and the final product is purified by crystallization of its dihydrochloride salt to >99% homogeneity.

Practical, stereoselective synthesis of palinavir, a potent hiv protease inhibitor

Preparation of (2S,4R)-4-Hydroxypipecolic Acid and Derivatives

Previous studies have shown that herpes virus ribonucleotide reductase can be inhibited by a synthetic nonapeptide whose sequence is identical to the C-terminal of the small subunit of the enzyme. ...

Pierre Lavallee

Papers

The Preparation and Synthetic Utility of tert-Butyldiphenylsilyl Ethers

A stereospecifie, total synthesis of thromboxane B2

Practical, stereoselective synthesis of palinavir, a potent hiv protease inhibitor

Preparation of (2S,4R)-4-Hydroxypipecolic Acid and Derivatives

Specific inhibition of ribonucleotide reductases by peptides corresponding to the C-terminal of their second subunit.