Yves Langelier

TL;DR: Evidence that a decrease in cardiolipin levels and altered mitochondrial function are involved in palmitate-induced breast cancer cell death is provided, and it is suggested that the antiapoptotic action of oleate on palmitates-induced cell death involves both restoration of cardiolips levels and redirection of palMITate esterification processes to triglycerides.

TL;DR: The results support the concept that PI3-K is implicated in the control of breast cancer cell growth by FFAs and that PI2-K may provide a link between fat and cancer and the view that the type of FFA and their ratios in the diet in addition to the total amount of fat influence mammary carcinogenesis.

TL;DR: The data indicate that the phospholipase C, MEK 1/2, Src, and phosphatidylinositol 3-kinase/protein kinase B signaling pathways are implicated in the proliferative signal induced by oleate and that these effects are mediated at least in part via the G protein-coupled receptor GPR40.

TL;DR: Two new adenovirus expression cassettes are constructed that significantly improve the utility of the adenvirus system for high-level expression of recombinant proteins in animal cells and will undoubtedly find useful applications in gene therapy.

TL;DR: It is proposed that a chronic increase in endothelial apoptosis and/or increased sensitivity of fibroblasts to mediators produced by apoptotic EC could form the basis of a fibrotic response characterized by sustained induction of an antiapoptotic phenotype in fibro Blasts and persistent myofibroblast differentiation.