抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Behavioral scientists routinely publish broad claims about human psychology and behavior in the world's top journals based on samples drawn entirely from Western, Educated, Industrialized, Rich, and Democratic (WEIRD) societies. Researchers - often implicitly - assume that either there is little variation across human populations, or that these "standard subjects" are as representative of the species as any other population. Are these assumptions justified? Here, our review of the comparative database from across the behavioral sciences suggests both that there is substantial variability in experimental results across populations and that WEIRD subjects are particularly unusual compared with the rest of the species - frequent outliers. The domains reviewed include visual perception, fairness, cooperation, spatial reasoning, categorization and inferential induction, moral reasoning, reasoning styles, self-concepts and related motivations, and the heritability of IQ. The findings suggest that members of WEIRD societies, including young children, are among the least representative populations one could find for generalizing about humans. Many of these findings involve domains that are associated with fundamental aspects of psychology, motivation, and behavior - hence, there are no obvious a priori grounds for claiming that a particular behavioral phenomenon is universal based on sampling from a single subpopulation. Overall, these empirical patterns suggests that we need to be less cavalier in addressing questions of human nature on the basis of data drawn from this particularly thin, and rather unusual, slice of humanity. We close by proposing ways to structurally re-organize the behavioral sciences to best tackle these challenges.

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The WEIRDest People in the World

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WEIRD languages have misled us, too [Comment on Henrich et al.]

Syntaxe comparative de l'anglais et de l'espagnol dans le cadre de la theorie des barrieres

Verb movement, universal grammar and the structure of IP

In a dynamic world, mechanisms allowing prediction of future situations can provide a selective advantage. We suggest that memory systems differ in the degree of flexibility they offer for anticipatory behavior and put forward a corresponding taxonomy of prospection. The adaptive advantage of any memory system can only lie in what it contributes for future survival. The most flexible is episodic memory, which we suggest is part of a more general faculty of mental time travel that allows us not only to go back in time, but also to foresee, plan, and shape virtually any specific future event. We review comparative studies and find that, in spite of increased research in the area, there is as yet no convincing evidence for mental time travel in nonhuman animals. We submit that mental time travel is not an encapsulated cognitive system, but instead comprises several subsidiary mechanisms. A theater metaphor serves as an analogy for the kind of mechanisms required for effective mental time travel. We propose that future research should consider these mechanisms in addition to direct evidence of future-directed action. We maintain that the emergence of mental time travel in evolution was a crucial step towards our current success.

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The evolution of foresight: What is mental time travel, and is it unique to humans?

Is calculation possible without language ? Or is the human ability for arithmetic dependent on the language faculty ? To clarify the relation between language and arithmetic, we studied numerical cognition in speakers of munduruku, an Amazonian language with a very small lexicon of numbers words. Our results imply a distinction between a non-verbal system of number approximation and a language-based counting system for exact number and arithmetic.

/pdf/exact-and-approximate-arithmetic-in-an-amazonian-indigene-1mh96jcq05.pdf

Exact and Approximate Arithmetic in an Amazonian Indigene Group

The mapping of numbers onto space is fundamental to measurement and to mathematics. Is this mapping a cultural invention or a universal intuition shared by all humans regardless of culture and education? We probed number-space mappings in the Mundurucu, an Amazonian indigene group with a reduced numerical lexicon and little or no formal education. At all ages, the Mundurucu mapped symbolic and nonsymbolic numbers onto a logarithmic scale, whereas Western adults used linear mapping with small or symbolic numbers and logarithmic mapping when numbers were presented nonsymbolically under conditions that discouraged counting. This indicates that the mapping of numbers onto space is a universal intuition and that this initial intuition of number is logarithmic. The concept of a linear number line appears to be a cultural invention that fails to develop in the absence of formal education.

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Log or Linear? Distinct Intuitions of the Number Scale in Western and Amazonian Indigene Cultures

Does geometry constitues a core set of intuitions present in all humans, regarless of their language or schooling ? We used two non verbal tests to probe the conceptual primitives of geometry in the Munduruku, an isolated Amazonian indigene group. Our results provide evidence for geometrical intuitions in the absence of schooling, experience with graphic symbols or maps, or a rich language of geometrical terms.

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Core Knowledge of Geometry in an Amazonian Indigene Group

All humans share a universal, evolutionarily ancient approximate number system (ANS) that estimates and combines the numbers of objects in sets with ratio-limited precision. Interindividual variability in the acuity of the ANS correlates with mathematical achievement, but the causes of this correlation have never been established. We acquired psychophysical measures of ANS acuity in child and adult members of an indigene group in the Amazon, the Mundurucu, who have a very restricted numerical lexicon and highly variable access to mathematics education. By comparing Mundurucu subjects with and without access to schooling, we found that education significantly enhances the acuity with which sets of concrete objects are estimated. These results indicate that culture and education have an important effect on basic number perception. We hypothesize that symbolic and nonsymbolic numerical thinking mutually enhance one another over the course of mathematics instruction.

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Education Enhances the Acuity of the Nonverbal Approximate Number System

This article claims that ione has to distinguish between X° reflexives which do not bear phi-features, such as number, and XP complex reflexive - which do bear such features. The presence/vs absence of features, it is argued, explains the behavior of so called long distance reflexives - first observed, within the generative tradition, in scandinavian languages - but present all over. The observation according to which XP reflexives are clause bound, while X° reflexives in argument position are not, is some times refered to as "Pica's generalization" (see Burzio (1987) which stressed correctly that is was the first time that such a correlatiion betwen reflexives structure, binding domains, and the role of a cycle was observed. The behavioir of reflexives it is argued derives from the properties of abstratc movement at the level of Logical Form.

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Pierre Pica

Papers

Exact and Approximate Arithmetic in an Amazonian Indigene Group

Log or Linear? Distinct Intuitions of the Number Scale in Western and Amazonian Indigene Cultures

Core Knowledge of Geometry in an Amazonian Indigene Group

Education Enhances the Acuity of the Nonverbal Approximate Number System

On the Nature of the Reflexivization Cycle