Showing papers by "Pierre-Vladimir Ennezat published in 2007"
Journal Article•
TL;DR: Bisoprolol fumarate is a selective beta-1 receptor blocker that significantly reduced morbidity and mortality in stable CHF patients and is well tolerated with few significant side effects in different large trials.
Abstract: Bisoprolol fumarate is a highly selective beta-1 receptor blocker. Bisoprolol has been extensively studied in three large mortality trials in stable chronic heart failure (CHF) patients. The CIBIS trial enrolled 641 patients and demonstrated the good tolerability of bisoprolol in a large CHF population, without evidence for any harmful effect. The CIBIS-II study was the first large randomized, double-blind, placebo-controlled study demonstrating in 2647 patients a dramatic reduction in mortality with a beta-blocking agent in CHF patients. CIBIS-III demonstrated in 1010 patients the equivalence of 2 different therapeutic strategies in de novo CHF patients. There was no difference in morbidity and mortality between sub-groups of patients receiving first bisoprolol or enalapril. These three trials also demonstrated the good tolerability of bisoprolol fumarate. Other studies were either limited in number of patients or not randomized. However, these studies confirmed the good tolerability of bisoprolol in CHF patients, even in elderly population. Bisoprolol fumarate is a selective beta-1 receptor blocker that significantly reduced morbidity and mortality in stable CHF patients. Bisoprolol is well tolerated with few significant side effects in different large trials.
17 citations
TL;DR: An 80-year-old woman was admitted for a diagnosis of severe pulmonary embolism and a large serpentine thrombus stuck in a patent foramen ovale (PFO) completely resolved without the patient experiencing any manifestation.
Abstract: An 80-year-old woman was admitted for a diagnosis of severe pulmonary embolism. A large serpentine thrombus stuck in a patent foramen ovale (PFO) completely resolved without the patient experiencing any manifestation. The right renal artery was the final destination. Thromboaspiration was unsuccessful. Three months later, the patient was diagnosed with a malignant melanoma and metastatic dissemination.
5 citations
Journal Article•
TL;DR: The authors report the case of an 84 year old woman admitted for a mild pulmonary embolism associated with severe hypoxaemia, which indicates the association of a right diaphragmatic paralysis with renewed patency of a foramenovale and creation of aright-to-left shunt is probably an underestimated cause of refractory hyp oxaemia.
Abstract: The authors report the case of an 84 year old woman admitted for a mild pulmonary embolism associated with severe hypoxaemia. The association of a right diaphragmatic paralysis with renewed patency of a foramenovale and creation of a right-to-left shunt is probably an underestimated cause of refractory hypoxaemia.
3 citations
Journal Article•
1 citations
Journal Article•
TL;DR: In this paper, le cas d'une thrombopenie induite a l'heparine severe normalisee 19 jours seulement apres l'arret de l'Heparine chez une patiente traitee initialement par heparine non fractionnee pour une embolie pulmonaire secondaire a une thrombo veineuse profonde extensive du membre inferieur droit.
Abstract: La thrombopenie induite a l'heparine est rare. Elle doit etre evoque devant une baisse d'au moins 40 % du taux de plaquettes et/ou un taux < 100 000/mm 3 chez un patient traite par heparine ou ayant recu de l'heparine dans les cent jours precedents. A l'arret de l'heparine, la re-ascension des plaquettes est classiquement rapide et la normalisation est obtenue en moins de sept jours. Nous rapportons le cas d'une thrombopenie induite a l'heparine marquee par une thrombopenie severe normalisee 19 jours seulement apres l'arret de l'heparine chez une patiente traitee initialement par heparine non fractionnee pour une embolie pulmonaire secondaire a une thrombose veineuse profonde extensive du membre inferieur droit.