Piet M. ter Wee

TL;DR: Microvascular function strongly relates to insulin sensitivity and blood pressure, consistent with a central role in linking these variables, and part of the variation in both blood pressure and insulin sensitivity could be explained by microv vascular function.

TL;DR: Identification of molecular pathways, cells, and cytokines involved in the development of angiogenesis, fibrosis, and membrane failure may lead to innovative therapeutic strategies that can protect the peritoneal membrane from the consequences of long-term PD.

TL;DR: It is demonstrated that MCs take up MGO and 3-DG and form early advanced glycation end-products, evidenced by increased VCAM-1 expression and elevated production of IL-6 and IL-8 and by positive staining with a monoclonal that specifically recognizes MGO-modified proteins, demonstrating complexing to mesothelial cellular proteins.

TL;DR: Treatment with sitagliptin or liraglutide does not affect measured renal hemodynamics, tubular functions, and markers of renal damage in overweight patients with type 2 diabetes without chronic kidney disease (CKD).

TL;DR: As melatonin amplitude and melatonin rhythm decreased with advancing renal dysfunction, follow-up research into circadian rhythms in patients with CKD is warranted.