Ping Chen

TL;DR: Using a large panel of unique antispore monoclonal antibodies, it is demonstrated that BclA is the immunodominant antigen on the B. anthracis spore surface and showed that the B clA protein and not a carbohydrate constituent directs the dominant immune response.

TL;DR: Production of mutacins I and IV by UA140 appears to be regulated by different mechanisms under different physiological conditions, and the significance of producing two mutacin by one strain under different conditions and the implication of this property in terms of the ecology of S. mutans in the oral cavity are discussed.

TL;DR: This study demonstrated that two O-linked oligosaccharides are released from spore- and exosporium-associated BclA by hydrazinolysis, and determined that the structure of the tetrasaccharide is 2-O-methyl-4-(3-hydroxy-3-methylbutamido)-4,6-dideoxy-β-d-glucopyranosyl-(1→3)-α-l-rhamn

TL;DR: The cloned and sequenced the mutacin III biosynthesis gene locus from a group III strain of S. mutans, UA787, consistent with the supposition that mutac in III has posttranslational modifications similar to those of the lantibiotic epidermin.

TL;DR: It is shown that recombinant BclA, encoded by the B. anthracis Sterne strain and synthesized in Escherichia coli, forms a collagen-like triple helix as judged by collagenase sensitivity and circular dichroism spectroscopy, and observed that CTD trimers are resistant to many proteases and readily form large crystalline sheets.